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Immunologically reactive to itself. Used of a cell or antibody.
References in periodicals archive ?
First, PRV-031 that inhibits self-reactive T cells responsible for causing the autoimmune damage to the insulin producing beta cells of the pancreas.
The 2018 edition examines the evolution of alternative adaptive immune systems in vertebrates, human T cell leukemia virus type 1, immune responses in the liver, host control of fungal infections, self-reactive B cells in the germinal center reaction, and regulation of the cell biology of antigen cross-presentation.
"Because of the role of the PD-1 pathway in the inhibition of self-reactive T cells, PD-1 inhibition might lead to inflammation because of immune-related adverse effects."
In another study, researchers from the University of Florida created a gene therapy that stimulates Tregs to curb self-reactive effector T-cells, thereby protecting myelin.
(8,9) When B cells reactive to NA or NA-containing self-antigens recognize these antigens, signaling through BCR together with signaling through NA sensors induces activation of self-reactive B cells, leading to production of anti-NA antibodies.
"Using a clinically tested gene therapy platform, we are able to induce very specific regulatory cells that target the self-reactive cells that are responsible for causing multiple sclerosis," said Brad E.
Because of shared features found in a number of HIV-1 bnAbs, scientists suspected the inability or delayed ability to make these type of protective antibodies against HIV was due to the immune system suppressing production of the antibodies to prevent the body from creating self-reactive antibodies that could cause autoimmune diseases like systemic lupus erythematosus.
While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T (Treg) cells.
Central immune tolerance is the thymic mechanism that eliminates self-reactive T cell receptor-producing cells.
It has traditionally been postulated that self-reactive lymphocytes are deleted in the thymus.
Autoimmune disease occurs when specific immune responses (activated self-reactive T-cells and antibodies) are directed against the body, leading to chronic inflammation and injury to cells, tissues, organs and blood vessels.