self-reactive

Also found in: Medical.

self-re·ac·tive

(sĕlf′rē-ăk′tĭv)

adj.

Immunologically reactive to itself. Used of a cell or antibody.

References in periodicals archive ?

First, PRV-031 that inhibits self-reactive T cells responsible for causing the autoimmune damage to the insulin producing beta cells of the pancreas.

Palmer: PRV-031 could be first ever disease modifying type 1 diabetes therapy

The 2018 edition examines the evolution of alternative adaptive immune systems in vertebrates, human T cell leukemia virus type 1, immune responses in the liver, host control of fungal infections, self-reactive B cells in the germinal center reaction, and regulation of the cell biology of antigen cross-presentation.

Annual Review of Immunology; Volume 36, 2018

"Because of the role of the PD-1 pathway in the inhibition of self-reactive T cells, PD-1 inhibition might lead to inflammation because of immune-related adverse effects."

Uveal Effusion Reported After Initiation of Anti-PD-1, -PD-L1; Case series IDs three patients who developed uveal effusion within one to two months of initiating tx

In another study, researchers from the University of Florida created a gene therapy that stimulates Tregs to curb self-reactive effector T-cells, thereby protecting myelin.

Newly Discovered Dysfunction in T-cell Development Sheds Light on Multiple Sclerosis

(8,9) When B cells reactive to NA or NA-containing self-antigens recognize these antigens, signaling through BCR together with signaling through NA sensors induces activation of self-reactive B cells, leading to production of anti-NA antibodies.

Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen

"Using a clinically tested gene therapy platform, we are able to induce very specific regulatory cells that target the self-reactive cells that are responsible for causing multiple sclerosis," said Brad E.

Unique Gene Therapy Reverses MS in Animals

Because of shared features found in a number of HIV-1 bnAbs, scientists suspected the inability or delayed ability to make these type of protective antibodies against HIV was due to the immune system suppressing production of the antibodies to prevent the body from creating self-reactive antibodies that could cause autoimmune diseases like systemic lupus erythematosus.

Immune system may help in neutralising body from HIV-1 virus

While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T (Treg) cells.

ThymusTolerance: Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus

Exploding Bomb - This category includes explosives and self-reactive agents.

Chemical safety: Is your practice up to date? what you need to know about chemical product labeling and safety data sheets

Central immune tolerance is the thymic mechanism that eliminates self-reactive T cell receptor-producing cells.

The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases

It has traditionally been postulated that self-reactive lymphocytes are deleted in the thymus.

Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection

Autoimmune disease occurs when specific immune responses (activated self-reactive T-cells and antibodies) are directed against the body, leading to chronic inflammation and injury to cells, tissues, organs and blood vessels.