Bristol-Myers and Gritstone Oncology announced that the companies have entered into a clinical trial collaboration to evaluate the safety and tolerability of Gritstone's personalized neoantigen immunotherapy, GRANITE-001, which comprises sequential delivery of neoantigens to patients within an adenovirus-based vector and a
self-replicating RNA-based vector, in combination with Bristol-Myers Squibb's programmed death-1 immune checkpoint inhibitor, Opdivo and Opdivo plus Yervoy, in patients with advanced solid tumors.
The lab has determined that tau protein in the human brain can form many distinct strains, or
self-replicating structures, and developed methods to reproduce them in the laboratory.
RepRap (rep rap.org) is "humanity's first general-purpose
self-replicating manufacturing machine." In addition to RepRap printers, you can search for "Core XY" at thingiverse.com to find others.
"Soon we hope to turn primitive chemistry into a
self-replicating information carrier that is protected from decay to a certain extent," says Boekhoven.
"The WannaCry ransomware attack in May spread rapidly and randomly due to its use of a
self-replicating worm.
Their topics include, iterative circuit computers, nonlinear environments permitting efficient adaptation, a new kind of turnpike theorem, genetic algorithms and the optimal allocation of trials, and studies of the spontaneous emergence of
self-replicating systems using cellular automata and formal grammars.
Wormable malware-- Some of the biggest cyber incidents in 2017 revolved around the issue of
self-replicating malware that can spread between networks.
Memphis Meats takes live
self-replicating animals cells, puts them in oxygen-rich nutrients environment and leaves them to divide naturally.
Information exchange between
self-replicating structures of any kind, such as electromagnetic 'bumps' in a chaotic 'soup,' might also qualify."
EMD Millipore Corp.'s Simplicon RNA Reprogramming Technology system uses a single synthetic, polycistronic
self-replicating RNA replicon containing four reprogramming factors, OCT-4, KLF-4, SOX-2 and GLIS-1, and allows for efficient reprogramming without viral intermediates or host genome integration.
THE INCREASING PREVALENCE OF PATENTABLE
SELF-REPLICATINGThe strong push to bring previous designs closer to the hands of general consumers can largely be credited to 2005's RepRap (Replicating Rapid-prototyper) Project, a British initiative to create open source,
self-replicating 3D Printers, released under a free software license for anyone in the community to edit or improve upon.
