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Tolerance by the body's immune system to its own cells and tissues.
References in periodicals archive ?
The immune center recognizes these specific antigens as self-components and forms self-tolerance and does not produce lymphocytes to attack these antigens.
Disturbed self-tolerance accompanied by the increased antigen presentation is a prerequisite for the HT occurrence, whereas proper interaction of thyroid cells, antigen presenting cells, and T cells are necessary for the initiation of thyroid autoimmunity.
There was a low incidence of immune-meditated toxicities such as colitis, dermatitis and infusion reactions--consistent with the proposed mode of action of CTLA-4 checkpoint inhibitors in maintaining self-tolerance. Overall, the findings in cynomolgus monkeys correlated with findings in humans, although with less frequency and therefore potentially under predicting the findings in the clinic--linking back to the status of the immune system in animal models compared to humans in clinical studies.
Of the many immune-regulatory functions of sema3A, one should mention its involvement in the maintenance of self-tolerance. Semaphorin3A triggers a pro-apoptotic process by sensitizing leukemic T cells to Fas (CD95)-mediated apoptosis.
The aim of the trial is to test if the combination of oncolytic virus and immune checkpoint inhibitor therapy can activate the immune system to fight cancer and overcome self-tolerance to colon cancer.
Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen Takeshi TSUBATA
(30) Thus, SHP-1 plays a crucial role in the prevention of lupus-like disease by maintaining self-tolerance of B cells.
[CD4.sup.+][CD25.sup.+][FoxP3.sup.+] regulatory T cells (Tregs) are critical mediators of self-tolerance [8] and have been shown to prevent autoimmunity and to induce (transplantation) tolerance in numerous experimental animal models [9-11].
DEL106 is a novel IL-2 mutein Fc fusion protein designed to preferentially upregulate regulatory T cells (Tregs), immune cells that are critical to maintaining natural self-tolerance and immune system homeostasis.
Loss of self-tolerance leads to imbalance of effector and regulatory cells, which plays a crucial role in the onset and pathogenesis of RA [2, 3].