To achieve this, lead author Alireza Delfarah, a graduate student in the Graham lab, focused on senescence
, a natural process in which cells permanently stop creating new cells.
A graduate student working under him at the Graham lab, lead author Alireza Delfarah, decided to study the process during which cells stop proliferating called senescence
. When senescence
occurs, it could manifest in a host of diseases such as arthritis, osteoporosis and cardiovascular trouble.A
First, we force the cancer cells to age prematurely i.e., we force them into senescence
. This is the first therapeutic punch.
is the permanent cell cycle arrest evoked in response to a variety of stressors (1).
or biological aging is inevitable but health experts recommend proper diet, healthy lifestyle, and optimism to help delay aging.
More alarming, the presence of just a few senescent cells produced a snowball effect, triggering senescence
in a larger number of previously healthy cells.
(6,7,8,9,10,11) Our goal was to investigate the effects of anti-VEGF drugs on viability, apoptosis, proliferation, and senescence
in retinal pigment epithelium (RPE) cell culture, which can serve as an in vitro model.
Aims: The purpose of this study was to investigate the effects of glucosamine (GlcN) on hydrogen peroxide (H[sub]2O[sub]2)-induced premature senescence
in human retinal pigment epithelial (RPE) cells in vitro.
At the same time, senescence
plays an important role in the pathogenesis of chronic lung diseases including COPD and lung fibrosis as well .
This special issue is focused on the factors involved in ripening, senescence
, and deterioration of harvested tropical and subtropical fruits and the postharvest technologies to restrict loss and ensure the maximum quality value.
The intracellular molecular mechanism of such effects is still unclear, which may involve oxidative stress , gene instability , and the regulation of p53 and p16 [18, 20, 21], but many experimental studies imply that in principle, hypoxia promotes MSC long-term expansion by slowing down replicative senescence
, that is, the inherent division limitation of cultured cells even in an ideal environment [11, 12, 16, 22].