A biomedical engineering student's question about a concept taught in every first-year neuroscience course, the "receptive field" features for which a sensory neuron
is activated led to an hourslong discussion that resulted in a complete reorganization of the experiment we were conducting together.
And the sensory neuron
could regulate MC3T3-E1 cells through exocytosis of glutamate and substance P, and it was confirmed that the peptidergic neurons were involved in this process .
The peripheral pathway of GI visceral pain mainly refers to the primary sensory neuron
stage of signal transmission through primary afferent nerve fibers to the spinal DRG after noxious stimulation acting on the receptors in the GI mucosa.
The western blot technique employed in those studies does not allow discrimination of the cell localization where PKC[epsilon] inhibition of translocation occurs, but a contribution of presynaptic PKC[epsilon], present in the central terminal of the sensory neuron
, consistent with the one we report here, is largely possible.
They discuss structural characterization of EPAC by x-ray crystallography; sensory neuron
cAMP signaling in chronic pain; monitoring real-time cyclic nucleotide dynamics in subcellular microdomains; identifying complexes of adenylyl with A-kinase anchoring proteins; assessing cyclic nucleotide binding domain allostery and dynamics by nuclear magnetic resonance spectroscopy; a protocol for expression and purification of cyclic nucleotide-free protein in E.
They cover both neuropathic pain recognized in sensory neuron
disorders and other types of pain less commonly considered, including in Parkinson's disease, amyotrophic lateral sclerosis, and muscle diseases.
The proposed mechanism involves activation of AMPK by metformin, with resultant inhibition of the mTOR (mammalian 'target of rapamycin) pathway leading to reduced sensory neuron
excitability and decreased chronic neuropathic pain (Nat.
As the muscle is stretched (e.g., by a tendon tap or in the course of daily activities), the muscle spindle is also stretched, generating a faster frequency of action potentials in the sensory neuron
(see Figure 2a).
Neurotrophin 4 (NT-4): Research in mice suggests the absence of this neurotrophic protein may result in sensory neuron
loss as well as deficits in long-term memory.
Neuronal Class Description S1 OLL Head sensory neuron
URY Head sensory neuron
IL2 Head sensory neuron
RIH Ring interneuron ASH Amphids; sensory neuron
RIM Ring motor neuron RIV Ring motor/interneuron CEP Head sensory neuron
AVH Interneuron ADL Amphids; sensory neuron
S2 SMD Ring motor neuron RME Ring motor neuron RMD Ring motor neuron AVB Command interneuron AVA Command interneuron AVE Command interneuron AVD Command interneuron TABLE 6.3 Neuronal class and type for bipartite subgraph found in the global network of 191 neurons of the C.
Distribution of dihydropyridine and omega-conotoxin-sensitive calcium currents in acutely isolated rat and frog sensory neuron
somata: diameter-dependent L channel expression in frog.
The way the senses work is that a sensory neuron
responds to a "bit" of information about the environment such as red photons, a sound frequency, a pressure differential or a chemical concentration, etc.--the senses we call sight, hearing, touch, pain, smell and taste.