sequestrant


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se·ques·trant

 (sĭ-kwĕs′trənt)
n.
A chemical that promotes sequestration.

sequestrant

(sɪˈkwɛstrənt)
n
(Horticulture) chem any substance used to bring about sequestration, often by chelation. They are used in horticulture to counteract lime in the soil
References in periodicals archive ?
Ironwood is also advancing two late-stage GI product candidates: IW-3718 is a gastric retentive formulation of a bile acid sequestrant being developed for the potential treatment of persistent gastroesophageal reflux disease, and MD-7246 is a delayed-release formulation of linaclotide that is being evaluated as an oral, intestinal, non-opioid, pain-relieving agent for patients suffering from abdominal pain associated certain GI diseases.
We are also advancing two late-stage, first-in-category GI product candidates: IW-3718 is a gastric retentive formulation of a bile acid sequestrant being developed for the potential treatment of persistent gastroesophageal reflux disease, and MD-7246 is a delayed-release formulation of linaclotide that is being evaluated as an oral, intestinal, non-opioid, pain-relieving agent for patients suffering from abdominal pain associated with IBS with diarrhea.
Adipic acid is predominantly used as a buffer, acidifier, gelling aid, and sequestrant. It is utilized in confectionery, fats, cheese analogs, flavoring extracts, and fats.
If high-intensity statin therapy is advisable but not acceptable to, or tolerated by, the patient, it might be reasonable to add a nonstatin drug (ezetimibe or a bile-acid sequestrant) to moderate-intensity statin therapy.
Colesevelam hydrochloride: Usefulness of a specifically engineered bile acid sequestrant for lowering LDL-cholesterol.
Clinically, BAM is classified as follows [3]: type 1: ileal dysfunction/resection (Crohn's disease); type 2: primary or idiopathic, characterised by watery diarrhea with (IBS) or without (FD) pain responding to bile acid sequestrant drugs (BASs); type 3: associated with other gastrointestinal disorders such as coeliac disease, small intestinal bacterial overgrowth (SIBO), and chronic pancreatitis; and type 4: due to an impaired FGF-19 feedback inhibition that causes excessive BA synthesis [4].
Fish scales can be seen in histologically processed gallbladder calculi (A), dystrophic calcifications (B), unspecified luminal material (favor food; C), and occasionally in large bile acid sequestrant fragments (see Figures 4, C and F, and 5), suggesting that fish scales are a histologic artifact of knife-cutting.
IW-3718 is a novel formulation of a bile acid sequestrant designed to release in the stomach over an extended period of time, bind to bile that refluxes into the stomach, and potentially provide symptomatic relief in uncontrolled GERD.
Historically this condition was treated with cholestyramine powders; although now almost redundant in this area of treatment this bile acid sequestrant was effective in converting cholesterol into bile acids, which were excreted from the body effectively.
Colesevelam is a bile acid sequestrant that lowers HbAlc, fasting plasma glucose, and low-density lipoprotein cholesterol (Fonseca, Handelsman, & Staels, 2010).
A green, healthy lawn that isn't just aesthetically-pleasing, it actually has real environmental benefits like reducing water runoff and soil erosion, acting as a water filter, providing a cooling effect, acting as a greenhouse gas sequestrant and oxygen generator.
Ideally, we should develop new strategies that could reduce the risk, such as possibly earlier treatment with a bile-acid sequestrant or niacin.