In November 2017, Sanofi released results of its long-term follow-up study which showed that the vaccine could cause an increased risk to those who are seronegative
or not yet infected with dengue.
The company's randomised, observer-blind, placebo-controlled and dose-ranging study has been framed to evaluate the safety, tolerability and immunogenicity of mRNA-1893 in healthy flavivirus seropositive and seronegative
adults aged between 18 and 49 years.
The Department of Health and experts from the University of the Philippines Philippine General Hospital have said there has been no conclusive link between Dengvaxia and any death even among seronegative
vaccine recipients, or those who have never had dengue.
They were especially interested in the 969 seropositive (as opposed to seronegative
) patients, who have auto-antibodies related to the disease and generally have more severe symptoms, including joint deformities and disability.
On the other hand, there was no association of smoking with seronegative
RA - when patients have no antibodies in their blood that help identify the disease - suggesting a different pathogenesis than seropositive RA, said the study, published in the journal, Arthritis Care & Research.
When someone is diagnosed with arthritis, a blood test will reveal if the patient is seropositive or seronegative
. This refers to the presence of an antibody in the blood that's known as the rheumatoid factor.
It also cited the failure of the DOH under Garin to conduct proper screening of Dengvaxia recipients and to implement an active and aggressive monitoring and surveillance over the recipients considering the risks posed by the vaccine to seronegative
recipients, or those who had no history of dengue.
"The President probably took notice of the fact that if there is a way we can find out if seronegative
children were given shots then we would know for sure if this was the principal cause of death," Gordon said in a statement.
pylori seropositive cases, compared with that of seronegative
ones (P value = 0.04).
In this article, the authors report a seronegative
case of NAE with normal serum zinc levels which has rarely been reported.
(21-24) Although many institutions have adopted universal leukoreduction policies, the question of providing leukoreduced blood products that are also CMV seronegative
for specific at-risk patient populations has remained unanswered.