* a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor
(SNRI) plus bupropion
Serotonin syndrome risk with triptans and antidepressants very low !-- -- The risk of serotonin syndrome developing in individuals who are taking both triptans for migraine and either an SSRI or serotonin-norepinephrine reuptake inhibitor
(SNRI) antidepressant is very low, according to analysis of electronic health record data of 47,968 patients prescribed triptans.
Thus, SSRI to SSRI switches do not appeal to me as much as switching from an SSRI to an SNRI (serotonin-norepinephrine reuptake inhibitor
) or to a compound with norepinephrine-dopamine effects (such as bupropion).
All participants also carried a diagnosis of major depression, depression NOS, or dysthymia for which they were taking a stable dose of a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor
Nausea and vomiting were more common with the serotonin-norepinephrine reuptake inhibitor
(SNRI) venlafaxine (33%) than with SSRIs (22%).
Sibutramine, a serotonin-norepinephrine reuptake inhibitor
marketed as Meridia by Abbott Laboratories, was approved in 1997 for adults, but it is not approved for pediatric use.
Milnacipran, a mixed serotonin-norepinephrine reuptake inhibitor
, was discovered by Pierre Fabre Medicament and has been developed for this purpose in collaboration with Cypress Bioscience and Forest Laboratories (NYSE:FRX).
SAN FRANCISCO -- The serotonin-norepinephrine reuptake inhibitor
venlafaxine is as effective as paroxetine in the treatment of panic disorder, Dr.
Levomilnacipran (Fetzima): a new serotonin-norepinephrine reuptake inhibitor
for the treatment of major depressive disorder.
The study was funded by Eli Lilly & Co., which is developing duloxetine, a serotonin-norepinephrine reuptake inhibitor
. It is being investigated for the treatment of stress urinary incontinence and also as an antidepressant.
The manufacturer of desvenlafaxine will conduct a 1-year study to resolve cardiovascular and hepatic safety concerns raised by the Food and Drug Administration in an "approvable" letter for the serotonin-norepinephrine reuptake inhibitor
, which is under review as a treatment for menopausal hot flashes and night sweats.
Drug Dosage Cost/Day venlafaxine 75-225 mg/day $2.61 (Effexor, (Effexor-XR) (150 mg) (*) Effexor-XR) mirtazapine 15-45 mg/day $2.61 (Remeron) (30 mg) (*) nefazodone 300-600 mg/day $2.70 (Serzone) (500 mg) (**) bupropion 300-450 mg/day $4.48 (Wellbutrin, (Wellbutrin) (400 mg) (*) Wellbutrin SR) Drug Comment (+) venlafaxine Serotonin-norepinephrine reuptake inhibitor
. Strongly (Effexor, inhibits norepinephrine and 5-hydroxytryptamine (5-HT) Effexor-XR) reuptake and weakly inhibits dopamine reuptake.