Based on these results, researchers suggested that the effect of roluperidone on BDNF and GDNF may indicate the potential of this investigational compound for disease modification and improved neuroplasticity, in addition to its observed effects on the sigma and serotoninergic
5-HT neurotransmitter pathways.
The enzymatic inhibition of the metabolism of citalopram by fluconazole can potentially induce serotoninergic
syndrome, due to a pharmacokinetic interaction with probable occurrence in hospitalized elderly patients, classified per severity as contraindicated.
Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: Implication of noradrenergic and serotoninergic
In conclusion, the longer latencies of R2-BR and enhanced ASR in akathisia suggest involvement of serotoninergic
pathways as well as dopaminergic pathways in akathisia.
The serotonin transporter (5-HTT) is an integral membrane protein responsible for the reuptake of 5-HT from the synaptic cleft, modulating the serotoninergic
(1-3) Similarly, despite significant variability in antidepressant response, (4) blockade of 65% to 80% of presynaptic transport proteins--such as the serotonin reuptake pumps when considering serotoninergic
antidepressants, (5,6) or the norepinephrine reuptake pumps when considering noradrenergic agents such as nortriptyline (7)--is necessary for these medications to be effective.
In addition, evidence suggests that paracetamol activates serotoninergic
descending pathways that inhibit nociceptive signal transmission within the spinal cord.
Functional activity of serotoninergic
and melatoninergic systems expressed in the skin.
For Paracetamol there is no evidence of interaction with lithium, but for opioids there is an increased risk for serotoninergic
There is currently growing theoretical and clinical concern in terms of drug-drug interaction when tramadol is used concomitantly with serotoninergic
emphasized the implication of the serotoninergic
, GABAergic, and MCHergic (melatonin-concentrating hormone) systems in REM sleep .
Recent evidences have revealed that chronic intake of high-fat diets produced changes in some neurotransmitter systems involved in the central regulation of hedonic and homeostatic properties of feeding, including dopaminergic (Carlin et al., 2016; Fordahl, Locke & Jones, 2016), serotoninergic
(Yu et al., 2013) and melanocortin system (Chandler, Viana, Oswald, Wauford & Boggiano, 2005; La Fleur et al., 2010).