serum sickness


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serum sickness

n.
A hypersensitive reaction to the administration of a foreign serum, characterized by fever, swelling, skin rash, and enlargement of the lymph nodes.

serum sickness

n
(Pathology) an allergic reaction, such as vomiting, skin rash, etc, that sometimes follows 2-3 weeks after an injection of a foreign serum
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Noun1.serum sickness - a delayed allergic reaction to the injection of an antiserum caused by an antibody reaction to an antigen in the donor serum
allergic reaction, allergy - hypersensitivity reaction to a particular allergen; symptoms can vary greatly in intensity
References in periodicals archive ?
BSA causes serum sickness and increases capillary permeability.
14) Hypersensitivity reactions can occur, resulting in anaphylaxis (type 1), anaphylactoid reactions (complement mediated), or delayed serum sickness (type 3), and are treated with a combination of diphenhydramine and epinephrine.
For patients with less severe symptoms, the authors recommend weighing the value of antivenin against the risks of acute hypersensitivity and delayed serum sickness.
Other causes include sarcoidosis, HIV, Kawasaki's disease, serum sickness and drug reaction.
Accelerated and delayed reactions are not IgE-mediated and those affected may develop a morbilliform rash, serum sickness, vasculitis, contact dermatitis, Stevens-Johnson syndrome or toxic epidermal necrolysis.
This will be counteracted by the induction of an antibody response directed against human IgG in the host, which may neutralize the injected antibodies and may induce serum sickness.
Other conditions in a differential diagnosis include viral eruption, angio-immunoblastic lymphadenopathy, vasculitis, Kawasaki disease, serum sickness, and exfoliative dermatitis (from psoriasis, dermatitis, or lymphoma, for example).