," which was demonstrated to be nagalase.
CD34, a glycosylated single-chain protein with an approximate weight of 116 kDa (11), is one of the single-pass transmembrane sialomucin
proteins and intercellular adhesion factors.
The mucin is diastase and hyaluronidase resistant sialidase labile, thus making it nonsulfated sialomucin
and distinguishable from hyaluronidasesensitive sulphomucin from other sweat gland tumors, basal cell carcinoma, lacrimal gland tumors, and metastatic mucinous adenocarcinoma of the gastrointestinal tract.
CD34 is a marker of lymphatic endothelial cells in human tumors.
In mesenteric lymph node HEVs, MAdCAM-1, a sialomucin
bearing two immunoglobulin-like domains, (15) serves as a vascular addressin, and [alpha]4[beta]7 integrin serves as the cognate lymphocyte receptor that mediates rolling and adhesion, (16) as described below.
Typical staining includes in situ antibody studies on multiple formalin-fixed sections for S100 (calcium-binding motif as Schwann cell marker), Ki-67 (nuclear nonhistone protein marker of cell proliferation), TP53 (tumor suppressor marker for transformation), CD34 (sialomucin
glycoprotein as nonspecific marker of endothelium and hematopoietic stem cells), and p16INK4a (cell-cycle inhibitory protein marker that is inactivated in MPNST).
have clearly stated that podocalyxin, a sialomucin
that is located in the glycocalyx, is not specific for podocytes .
Chan, "CD164-a novel sialomucin
on [CD34.sup.+] cells," Leukemia & Lymphoma, vol.
Endomucin Endomucin (endothelial sialomucin
; also endomucin-1/2 and mucin-14) is an 80-120 kDa glycoprotein member of the endomucin family of proteins.
Seed, "Molecular cloning of a cDNA encoding CD34, a sialomucin
of human hematopoietic stem cells," The Journal of Immunology, vol.
is found in the cytoplasm of Paget's cells.