sickle cell


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Related to sickle cell: sickle cell trait, Sickle cell crisis

sickle cell

n.
An abnormal, crescent-shaped red blood cell that results from a single change in the amino acid sequence of the cell's hemoglobin, which causes the cell to contort, especially under low-oxygen conditions.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

sick′le cell`



n.
an elongated, often sickle-shaped red blood cell, caused by defective hemoglobin.
[1925–30]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.sickle cell - an abnormal red blood cell that has a crescent shape and an abnormal form of hemoglobin
erythrocyte, RBC, red blood cell - a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Laboratory diagnosis of sickle cell anemia involves phenotypic testing for the presence of the sickle haemoglobin and genetic analysis.
"The Tuskegee experiment is fresh in a lot of people's minds even though that was decades ago," says Andemariam, who is also chief medical officer for the Sickle Cell Disease Association of America.
The investigators examined a possible link between Hb[A.sub.1c] and sickle cell trait, which affects hemoglobin even though it doesn't confer sickle cell disease, by analyzing data from two cohort studies involving African American adults.
The library being created by scientists at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) comprises blood samples from ethnically diverse patients with sickle cell disease from around the world and represents the major genetic backgrounds on which the sickle cell mutation occurred.
Sickle cell beta-thalassemia is a sickle cell variant syndrome and is characterized by the compound heterozygosity for sickle and beta-thalassemia genes.
Data from the firm's Phase three sickle cell disease trial indicated a decrease in the frequency of sickle cell crises and hospitalisations, and a reduction in cumulative days hospitalised, and a lower incidence of the life-threatening acute chest syndrome.
(1,2) According to a pediatric study, sickle cell pain may be the most important disease complication associated with decrements in physical and psychosocial domains of HRQOL.
CDC is also working with partners to develop the Sickle Cell Data Collection Program (http://www.cdc.gov/ncbddd/ hemoglobinopathies/scdc.html), which tracks health information of persons living with sickle cell disease in the United States throughout their lives.
Like sickle cell, it gets worse with age, requires strict daily drug regimens, and often results in hospitalization.
About 8 to 10 percent of African-Americans have sickle cell trait.
As free radical promotes increased and irreversible sickling of RBC membrane by damaging it, oxidative stress was assessed in sickle cell disease patients of western Odisha by measuring serum MDA as a by-product of lipid peroxidation, with simultaneous measurement of levels of antioxidant vitamins (vitamin E and vitamin C) as a possible beneficial therapeutic supplements in prevention of sickle cell complications.
All TLOD chapters have programs that benefit sickle cell disease research and families throughout the United States.