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Related to sickled: sickle cell, sicklied
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1. An implement having a crescent-shaped blade attached to a short handle, used for cutting grain or tall grass.
2. The cutting mechanism of a reaper or mower.
v. sick·led, sick·ling, sick·les
1. To cut with a sickle.
2. To deform (a red blood cell) into an abnormal crescent shape.
To assume an abnormal crescent shape. Used of red blood cells.
Shaped like the blade of a sickle; crescent-shaped: a sickle moon.

[Middle English sikel, from Old English sicol, from Vulgar Latin sicila, from Latin sēcula; see sek- in Indo-European roots.]
References in periodicals archive ?
The healthy cells will proliferate, and eventually, he says, they will outnumber the sickled ones.
Painful episodes can occur when sickled red blood cells, which are stiff and inflexible, get stuck in small blood vessels.
The peripheral blood smear is characteristically abnormal, with irreversibly sickled cells comprising 5-50% of red cells.
5] These permanently sickled RBCs cells fail to pass through narrow capillaries, leading to vessel occlusion and ischemia.
The new blood cells survive longer than sickled cells, which could also improve treatment outcomes.
A total of 112 sickled pregnant women were identified during the study period.
The sickled hemoglobin, referred to as Hemoglobin S, in the absence of oxygen, polymerizes, forming rods that develop the sickle or crescent shape of the red blood cell.
Histopathology revealed presence of sickled RBCs in cerebrum, cerebellum, liver, kidneys, adrenals and spleen.
Those sickled cells can cause blockages in blood vessels, stopping oxygen from reaching organs.