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Related to sideroblast: Myelodysplastic syndrome, ferritin
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Noun1.sideroblast - an erythroblast having granules of ferritin
erythroblast - a nucleated cell in bone marrow from which red blood cells develop
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References in periodicals archive ?
These mutations are highly correlated with the presence of ring sideroblast (RS).
Except for acquired clonal SA cases where a 'cut off' of 15% was used, only frequent observation of ring sideroblasts fulfilling the diagnostic criterion of a ring sideroblast was taken as positive finding for SA diagnosis.
(2) An SF3B1 mutation decreases the diagnostic ring sideroblast percentage from 15% or more to 5% or more for a diagnosis of myelodysplastic syndrome with ring sideroblasts (MDS-RS), although the threshold of 10% dysplasia on morphologic review remains.
(56) Moreover, among splicesome mutations, SF3B1 mutations are closely associated with a specific type of MDS, RARS (refractory anemia with ringed sideroblast); 57-75% of RARS patients harbor SF3B1 mutations.
Of the nine cases of myelodysplastic syndrome, four were refractory anemia (RA), one was refractory anemia with ring sideroblast (RARS), two were refractory cytopenia with multilineage dysplasia and two had refractory Anemia with excess blast (RAEB).
In pathological conditions, it can be easily detected as "ringed sideroblast" (42).
One of the most common causes of secondary acquired sideroblastic anaemia is chronic ethanol consumption, with a ringed sideroblast abnormality occurring in 25-30% of anaemic alcoholic patients (1,4,5).
reported a 40-year-old woman with a diagnosis of refractory anemia with ring sideroblast, who underwent an allogeneic HCT from a 32-year-old healthy male donor.
Patient samples and DNA isolation: Forty one MDS samples including 17 RA (refractory anaemia), 4 RARS (refractory anaemia ringed sideroblast), 9 RAEB (refractory anaemia excess blast), 6 RAEB-t (refractory anaemia excess blast in transformation) and 5 AML secondary to MDS (MDS/AML) according to the French-American-British (FAB) classification were used in the study.
(NASDAQ: XLRN) have received results from the pivotal, phase 3 MEDALIST trial evaluating the efficacy and safety of investigational luspatercept to treat patients with ring sideroblast myelodysplastic syndromes -associated anemia who require red blood cell transfusions and who had failed, were intolerant to, or ineligible for erythropoietin therapy, the companies said.
Hematological features consist of the unique combination of megaloblastic changes and the ring sideroblast abnormality, with variable degrees of neutropenia and thrombocytopenia.
Serum iron, total iron binding capacity, ferritin, hemosiderin, ferrokinetics and free erythrocyte protophorin are among further tests that could be done to assess and treat cases of lead poisoning in children in addition to bone marrow tests, such as: stainable iron stores, erythrocyte cellularity, sideroblast % and hemoglobin electrophoresis for Hb A2 and Hb F which increases during lead poisoning.