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A statin drug, C25H38O5, that blocks the body's synthesis of cholesterol and is used to lower cholesterol (especially LDL) levels and to reduce the risk of heart attack and stroke in individuals with elevated risk.

[sim- (perhaps alteration of syn-, pref. indicating attachment on the same side of the plane as a double bond; see syn-) + -vastatin, statin suffix; see pravastatin.]
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Noun1.simvastatin - an oral lipid-lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks
lipid-lowering medication, lipid-lowering medicine, statin, statin drug - a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase


n simvastatina
References in periodicals archive ?
In addition to these effects, few studies have shown that statins such as atorvastatin and simvastatin have analgesic and anti-inflammatory activities.
UK researchers have begun a GBP6m clinical trial set to investigate the potential of simvastatin in the treatment of multiple sclerosis, Pharma Times reported on Tuesday.
Objective: To evaluate the effect of azithromycin in combination with simvastatin in the treatment of chronic obstructive pulmonary disease (COPD) complicated by pulmonary arterial hypertension.
Ezetimibe and simvastatin tablets are a prescription medicine that contains two (2) cholesterol lowering medicines, ezetimibe and simvastatin, which are used along with diet to: Lower the level of bad cholesterol (low density lipoprotein cholesterol or LDL)
Her current medications included oral fluconazole 400 mg/d, simvastatin 20 mg/d, levothyroxine 88 mcg/d, pregabalin 75 mg/d, metformin 1000 mg twice daily, 6 units of subcutaneous insulin glargine at bedtime, and 2 units of insulin lispro with each meal.
The two groups (G1 and G2) were given toxic doses of simvastatin (60mg/kg/day) with and without Co Q10 (5mg/kg/day) orally for 14 days and rest of two groups (G3 and G4) were kept on therapeutic doses (1mg/kg/day) of simvastatin with and without Co Q10 (5mg/kg/day) orally for 90 days.
In addition, simvastatin was tested against biofilms of Candida spp.
Domestic simvastatin was developed by Sichuan Industrial Institute of Antibiotics.
7) Simvastatin is a part of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor or statins group of drugs, which act by inhibiting internal cholesterol synthesis inside the body.
Ezetimibe, like statin drugs--ator-vastatin (Lipitor[R]), rosuvastatin (Crestor[R]) and simvastatin (Zocor[R]) are examples--all lower LDL, but via different mechanisms.
SAN DIEGO--The sensational initial presentation of the landmark IMPROVE-IT trial at the American Heart Association scientific sessions last November told only half the story of the actual clinical impact of lip-id-lowering with the combination of ezetimibe and simvastatin as opposed to simvastatin alone.