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Adj.1.single-stranded - having a single strand; "single-stranded RNA"
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Once Cas12a encounters a target DNA sequence, also called a trigger, it cleaves the double-stranded DNA and transforms into an enzyme that can slice any single-stranded DNA it encounters.
Plasma DNA might display signs of DNA damage with 5' or 3' overhangs or single-stranded nicks mediated by DNase1 or other DNA-hydrolyzing enzymes (3).
Dubbed 'single-stranded origami,' their new strategy uses one long, thin noodle-like strand of DNA, or its chemical cousin RNA, that can self-fold -- without even a single knot -- into the largest, most complex structures to date.
"Ionis has made significant breakthroughs showing that chemically modified single-stranded oligonucleotides can activate the RNAi pathway.
20 mg single-stranded herringbone DNA was mixed into the magnetic fluid.
Later, many other examples emerged, showing that single-stranded DNAs and RNAs are capable to form complicated 3D structures, which allows them to specifically bind certain targets and even directly catalyze certain reactions.
In order for these specific primers to anneal, the template material must be single-stranded (ssDNA).
Presently, Smarticles is in clinical development delivering both a single-stranded and a double-stranded oligonucleotide through licensees ProNAi Therapeutics and Mirna Therapeutics, respectively.
The protein complex Replication factor A (Rfa) is a single-stranded DNA binding known to be involved in DNA replication, repair, recombination and cell cycle regulation (1).
Noroviruses are single-stranded RNA viruses that possess a non-enveloped protein capsid.
Measles is caused by the measles virus, a single-stranded, negative-sense enveloped RNA virus of the genus Morbillivirus within the family Paramyxoviridae.

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