The newly allowed patent broadly covers methods of cleaving a target RNA via a double-stranded ribonuclease mechanism, including the RNAi mechanism, with chemically modified, single-stranded
Issued patents in the Crooke estate already include United States Patent 5,898,031 covering RNA-containing therapeutic compounds, and United States Patent 6,107,094 covering methods of using these compounds to interfere with target RNA function, including not only interrupting protein production with single-stranded
and double-stranded (siRNA) antisense compounds but also targeting other RNAs, such as microRNAs.
For more than 40 years, researchers had known that RNA, a single-stranded
nucleic acid, carries instructions from a gene to the cell's protein-making machinery.
To the Editor: Torquetenovirus (TTV) and torquetenominivirus (TTMV) are characterized by a small, negative-sense, circular, single-stranded
DNA genome and by an extraordinary ability to produce chronic plasma viremia.
The abstract describes the technology as follows: Methods and Composition for producing single-stranded
cloned DNA (ss-cDNA) with a vector based system in eukaryotic cells.
In addition to targeting specific genes in the body, AVI's antiviral program uses NEUGENE antisense compounds to combat disease by targeting single-stranded
RNA viruses, including West Nile virus, hepatitis C virus, dengue virus, Ebola virus and influenza A virus.
Phase 2 SBIR Grant Funding to Advance the Development of Single-Stranded
Antisense RNAi Drugs
Turberfield, designed a set of four single-stranded
DNA molecules, each one with components in an order that would result in certain DNA-DNA bonds.
Cheil Jedang Corporation (Korea) has patented a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded
oligonucleotide including CpG motif which is involved in immune response.
So, he and his colleagues adorned some nanotubes with a layer of single-stranded
DNA, which binds to more kinds of molecules than naked carbon does.
In this technique, a complementary strand of RNA, the antisense strand, binds to part of a cell's normal, single-stranded
One factor may be molecules called single-stranded
DNA-binding (SSB) proteins, which have been implicated in the copying and repairing of genes.