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An immunosuppressive drug produced by the actinomycete Streptomyces hygroscopicus, C15H79NO13, used in combination with cyclosporine and corticosteroids to prevent rejection of transplanted tissues or organs. Also called rapamycin.

[si-, origin unknown + (tac)rolimus.]


n sirolimus m, sirolimús m (INN)
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M2 PHARMA-December 26, 2017-US FDA Requests Additional Information for Santen Prior to Approval of NDA for Intravitreal Sirolimus
Using the company's proprietary system, surgeons deliver the drug sirolimus to the AV fistula at and around the regions where the vein and artery are surgically connected.
Issue 1 - Stents releasing antiproliferative drug - Sirolimus or Evorolimus
15 It is important to be aware of the possible association of tacrolimus with hepatotoxicity in order to discontinue therapy and replace with sirolimus in cases of hepatotoxicity.
We present a case of GSD complicated with pleural effusion in which clinical and radiological remission was achieved with a single lead dose of sirolimus 4 mg and maintenance doses of 1.
Sirolimus, an inhibitor of the mammalian target of rapamycin (mTQR), is used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders.
Sirolimus protects organ-transplant recipients against developing skin cancer, reducing their risk by 40%, according to a recently published retrospective cohort study.
Nine of these patients were on immunosuppressive regimens that included mammalian target of rapamycin- (mTOR-) inhibitors (8 were treated with sirolimus [2, 5-7, 9] and 1 was treated with everolimus[4]), while 2 were on mTOR-inhibitor sparing regimens that included prednisone, a calcineurin inhibitor, and mycophenolate mofetil (MMF) [3,10].
Importantly, they also discovered that patients who took a particular immunosuppressant called sirolimus as part of their treatment regimen had fewer cells in their blood that were infected with HIV over time.
An immunosuppressant drug called sirolimus used by certain study patients showed they had fewer HIV-infected cells in their blood.