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Related to somatostatin: Octreotide


 (sō-măt′ə-stăt′n, sō′mə-tə-)
A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.


(Biochemistry) a peptide hormone that prevents the release of growth hormone from the pituitary gland
[C20: from somato- + -stat + -in]


(səˌmæt əˈstæt n)

a polypeptide hormone, produced in the brain and pancreas, that inhibits secretion of somatotropin from the hypothalamus and inhibits insulin production by the pancreas.
[1973; somato (tropin) + -stat + -in1]
References in periodicals archive ?
Falsepositive somatostatin receptor scintigraphy due to an accessory spleen.
Somatostatin analogues (octreotide and lanreotide) target somatostatin receptors commonly expressed in pancreatic NET and can lead to decreased hormone production, although they often have limited tumor regression effects (18).
6] Somatostatin receptors are present in 70% to 90% of NETs.
Somatostatin receptor (SSTR) scintigraphy is a whole-body imaging technique used for diagnosis, staging and restaging of NETs.
The use of radiolabeled somatostatin analog scintigraphy in the staging of small cell lung cancer patients.
68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT.
Nicolato evaluated the prognostic role of somatostatin receptor scintigraphy with the indium-111-labeled somatostatin analogue octreotide in 12 patients with skull base meningiomas who had undergone gamma knife radiosurgery.
During aging there are several changes which contribute to the decline in GH/IGF-I including changes in signal to the somatotrophs from growth hormone releasing hormone, somatostatin and other factors such as body composition, exercise, diet and sleep.
Occasional instances of sarcomatous transformation of fibrous dysplastic bones have been reported with radiation therapy (10,11), but radiotherapy may be an option for treatment of acromegaly in patients who have MAS when surgery is impossible and somatostatin analog therapy is ineffective (12).
alpha]-Cells secrete glucagon in response to low blood glucose, glucagon stimulates liver to release glucose through glycogenolys is and gluconeogenesis and it also stimulates adipose tissue to release fatty acids through lipolysis; [beta]-cells produce insulin that stimulate muscle, liver and adipose cells to store glucose for later use by synthesizing glycogen, protein and fats (Figure 1), [delta]-cells secrete somatostatin that inhibits insulin and glucagon release from their islet cells [10, 11].
The EO significantly increased the levels of motilin (MTL) and gastrin (GAS) and decreased the levels of somatostatin (SS) and CRF.

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