somatostatin


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Related to somatostatin: Octreotide

so·mat·o·stat·in

 (sō-măt′ə-stăt′n, sō′mə-tə-)
n.
A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.

somatostatin

(ˌsəʊmətəˈstætɪn)
n
(Biochemistry) a peptide hormone that prevents the release of growth hormone from the pituitary gland
[C20: from somato- + -stat + -in]

so•mat•o•stat•in

(səˌmæt əˈstæt n)

n.
a polypeptide hormone, produced in the brain and pancreas, that inhibits secretion of somatotropin from the hypothalamus and inhibits insulin production by the pancreas.
[1973; somato (tropin) + -stat + -in1]
References in periodicals archive ?
Leimer et al., "DOTA-lanreotide: a novel somatostatin analog for tumor diagnosis and therapy," Endocrinology, vol.
In distant metastatic disease the 5-year survival rate is only (20%-30%).[sup.6] Somatostatin receptors are present in 70% to 90% of NETs.
Somatostatin is a regulatory peptide, with affinity for G-protein-coupled membrane-bound SSTR subtypes 1-5, including 2A and 2B, which are overexpressed in NETs.
Somatostatin Receptor Expression and Functions in Normal Tissues
The funds are being used to support the ongoing research and development of Crinetics' nonpeptide somatostatin agonists for congenital hyperinsulinemias (CHI).
54 Somatostatin receptor analogues (SSAs) such as octreotide or lanreotide also have an impact on progression-free survival and are used as first-line in low grade NETs.
Somatostatin (SS)-14 inhibits the secretion of growth hormone (GH) and the growth of animals (Adams et al., 2015; Yang et al.
Cardiovascular effects of the somatostatin analog octreotide in acromegaly.
In the treatment of NETs, the peptide is a ligand for the membrane-bound somatostatin receptors.
Expression of somatostatin receptor type 2 and mammalian rapamycin target signaling activation patterns has also been reported.
Recently, it has been recognized that meningiomas have upregulated somatostatin receptor 2a (SSTR2a).
Postoperative somatostatin (250 [micro]g/h) was continuously administered, and enteral nutrition was provided via an indwelling nasal feeding tube.

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