Leimer et al., "DOTA-lanreotide: a novel somatostatin
analog for tumor diagnosis and therapy," Endocrinology, vol.
In distant metastatic disease the 5-year survival rate is only (20%-30%).[sup.6] Somatostatin
receptors are present in 70% to 90% of NETs.
is a regulatory peptide, with affinity for G-protein-coupled membrane-bound SSTR subtypes 1-5, including 2A and 2B, which are overexpressed in NETs.
Receptor Expression and Functions in Normal Tissues
The funds are being used to support the ongoing research and development of Crinetics' nonpeptide somatostatin
agonists for congenital hyperinsulinemias (CHI).
receptor analogues (SSAs) such as octreotide or lanreotide also have an impact on progression-free survival and are used as first-line in low grade NETs.
(SS)-14 inhibits the secretion of growth hormone (GH) and the growth of animals (Adams et al., 2015; Yang et al.
Cardiovascular effects of the somatostatin
analog octreotide in acromegaly.
In the treatment of NETs, the peptide is a ligand for the membrane-bound somatostatin
Expression of somatostatin
receptor type 2 and mammalian rapamycin target signaling activation patterns has also been reported.
Recently, it has been recognized that meningiomas have upregulated somatostatin
receptor 2a (SSTR2a).
(250 [micro]g/h) was continuously administered, and enteral nutrition was provided via an indwelling nasal feeding tube.