The treatment is divided into several stages: in the first stage, sonications are delivered at a very low energy to confirm that the focus is in the selected target.
The patients may also complain about headache that appears only during sonications. This type of headache can be severe, and in our experience, it may lead to discontinuation of the procedure.
A few low-energy sonications (usually up to 3 or 4) are performed for final targeting calibration.
Treatment duration was 3 h 55 min (calculated from the first to the last sonication); 102 sonications were performed with an HI-FU energy range of 1600 to 4500 J.
The operator uses the integrated system to deliver accurate energy pulses (termed sonications) to a location identified on anatomical T2 weighted MRI images.
The fibroid was treated using a total number of 28 sonication spots and treatment duration was 50 minutes (from first to last sonication) (fig.
tested the safety of this method by searching for ischemia and apoptosis in areas with BBB disruption induced by pulsed ultrasound in the presence of gas bubbles and by looking for posttreatment effects up to one month after sonication
. Pulsed ultrasound exposures (sonications
) were performed in the brains of rabbits under monitoring by MRI.
The temperature increase during the sequential, 'sonications
', each lasting 10 to 20 seconds, is continuously displayed and controlled on precise MR-temperature distribution maps.
An additional regular sonication
was used at the end to cover a marginal dose region at the lateral aspect of the treated region.