Cross-reactivity in serological tests for Lyme disease and other spirochetal
Treponema denticola is among the most frequently isolated oral spirochetal
species in patients with periodontitis [266, 267].
Imaging of rickettsial, spirochetal
, and parasitic infections.
The result is that a devastating shower of spirochetal
blebs containing OspA floods the bloodstream in many individuals who are bitten by a tick and their immune system is immediately compromised.
"Lyme disease, which is caused by a spirochetal
bacterium transmitted to humans through the bite of the deer tick, has reached epidemic proportions in areas of the northeastern United States;' says Allen Steere, MD, Principal Investigator of MGH's Center for Immunology and Inflammatory Diseases and Director of Translational Research for the Rheumatology Unit at MGH.
The five miRNAs that were found at low levels among the patients in group 1 were higher in these patients, which "suggested that the nature of the arthritis had changed after spirochetal
killing." The higher miR-223 levels seen in group 1 also occurred in group 2.
Several strong immunogenic antigens that induced a high antibody response during syphilis infection and are not cross-reactive with serum from patients with other spirochetal
diseases have been identified.
These assays use a whole-cell sonicate of B burgdorferi and yield a significant number of false-positive results due to cross-reactive antigens such as flagellar and heat-shock proteins if other spirochetal
infections are present.
antigens and lymphoid cell surface markers in Lyme synovitis: comparison with rheumatoid synovium and tonsillar lymphoid tissue.
Bacterial and spirochetal
diseases transmitted by them include rick-ettsial diseases such as Rocky Mountain Spotted Fever, ehrlichiosis, and anaplasmosis.
Differential diagnoses of disseminated cutaneous sporotrichosis include fungal, bacterial, mycobacterial and spirochetal
infections and inflammatory diseases, e.g., pyoderma gangrenosum, polyarteritis nodosa, vasculitis, sarcoidosis, Sweet's syndrome, and prurigo nodularis.
burgdorferi genes was detected in host tissues, flaB DNA was acquired by xenodiagnostic ticks, and spirochetal
forms could be visualized within ticks and mouse tissues by immunofluorescence and immunohistochemistry, respectively (Figure 5).