spironolactone


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spi·ro·no·lac·tone

 (spī′rə-nō-lăk′tōn, spī-rō′-, spī-rŏn′ə-)
n.
An aldosterone antagonist and antiandrogen, C24H32O4S, that promotes diuresis and is used to treat fluid retention, androgenic syndromes in women, and hypertension.

[Alteration of spirolactone : Latin spīra, coil; see spiral + lactone.]

spironolactone

(ˌspaɪrənəʊˈlæktəʊn)
n
(Pharmacology) a diuretic that increases water loss from the kidneys and is much used to treat oedema in heart and kidney failure
[C20: from spiro-2 + linking syllable -no- + lactone]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.spironolactone - a synthetic corticosteroid (trade name Aldactone) used to treat hypertensionspironolactone - a synthetic corticosteroid (trade name Aldactone) used to treat hypertension
antihypertensive, antihypertensive drug - a drug that reduces high blood pressure
adrenal cortical steroid, corticoid, corticosteroid - a steroid hormone produced by the adrenal cortex or synthesized; administered as drugs they reduce swelling and decrease the body's immune response; "adrenal cortical steroids are used to treat many different conditions"
Translations

spironolactone

n espironolactona
References in periodicals archive ?
Patients who were excluded from GISSI-HF were older and more often female; had higher BMI, systolic blood pressure, and NYHA class; and more rarely used ACE-Is, [beta]-blockers, and spironolactone (see online Supplemental Table 3).
Importantly, patients will still need to continue their other heart medications, such as beta-blockers (e.g., metoprolol and carvedilol) and aldosterone blockers (e.g., spironolactone).
The dog was treated with Propanolol @) 0.2 mg/ kg twice daily, Digoxin @ 0.25 mg daily PO, Spironolactone @ 1mg/kg twice daily and Enalapril @ 0.25 mg/kg twice daily for 7 days.
Spironolactone, usually used for high blood pressure and heart failure, could help people suffering from osteoarthritis.
In this paper in the British Medical Journal the authors report on a study that investigates whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years of age.
In the United States, spironolactone is the only antiandrogen treatment option.
The patient had a history of diabetes mellitus and liver cirrhosis with ascites; he had been taking a potassium-holding diuretic, spironolactone, for 8 months.
For starters, Amneal Pharmaceuticals LLC has received a green light from the FDA to manufacture spironolactone HCI tablets in 25-, 50- and 100-mg strengths.
Use of renin -angiotensin-aldosterone system blockers (angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and spironolactone) and their association with postoperative AF (AF episode lasting > 5 min) were evaluated.
Aldosterone antagonists, which include spironolactone, work by inhibiting sodium resorption in the kidneys and interfering with the sodium-potassium exchange in the blood.
He reported on 64 inpatients and outpatients with major depression who were placed on escitalopram (Lexapro) at 10-20 mg/day and randomized 2:2:1 to 3 weeks of double-blind fludrocortisone at 0.2 mg/day, spironolactone at 100 mg/day, or placebo.
For patients who are allergic to sulfa-containing diuretics, doctors sometimes prescribe triamterene, spironolactone, amiloride, or ethacrynic acid.