A study published in the journal BMJ Open Diabetes Research and Care identifies the specific drugs as stavudine
or first-generation ARVs including nelfinavir or indinavir.
40Mg Plus Lamividine 150Mg Plus Neviparine 200Mg
The combination of didanosine and stavudine
was associated with the highest risk.
tablet; 10 mg/ mL oral, IV solution Stavudine
40 mg b.
SHL and LA are related to the use of nucleoside reverse transcriptase inhibitors (NRTIs), occurring most frequently with zalcitabine, stavudine
(d4T), didanosine, zidovudine (AZT), and lamivudine and least frequently with abacavir/tenofovir.
The declining use of stavudine
along with a shift to zidovudine/tenofovir-based regimen in our hospital could account for the difference in prevalence of ADRs.
2] Additionally, stavudine
has been replaced with a safer alternative, tenofovir.
Distribution of patients by regimen shows that 14 of males and 45 of the females were on stavudine
30 mg/ lamivudine/nevirapine (D4T30/3TC/NVP/1a30) at the initiation of ART, accounting for 71.
1%) were receiving lamuvidine, stavudine
and efavirenz; 27% were receiving lamuvidine, stavudine
and nevirapine; 5% were receiving zidovudine, lamuvidine and efavirenz; 4.
is still recommended where side-effects are tolerated (8).
The immunity-from-suit agreement signed with Matrix Laboratories Limited, a Mylan Company, enables the generic company to manufacture and sell atazanavir, as well as stavudine
and didanosine, in sub-Saharan Africa and India.
However, resource constraints limit the national programme to use nucleoside reverse transcriptase inhibitors (NRTIs) like zidovudine (AZT) or stavudine
(d4T) with lamivudine (3TC) and non nucleoside reverse transcriptase inhibitors (NNRTI) like nevirapine and efavirenz for highly active anti-retroviral therapy (HAART).