Hammoud et al., "Cardiomyocyte-specific overexpression of human stem cell factor
improves cardiac function and survival after myocardial infarction in mice," Circulation, vol.
The culture was separated into 4 groups: (1) 4 factors in cIMDM (4F cIMDM): IMDM + 10% FBS + Flt3-ligand (Flt3-L, 100 ng/mL), stem cell factor
(SCF, 100 ng/mL), interleukin-6 (IL-6, 100 ng/mL), and thrombopoietin (TPO, 10 ng/mL); (2)5F in cIMDM (5F cIMDM): IMDM + 10% FBS + Wnt1 (20 ng/mL) + Flt3-L (100 ng/mL), SCF (100 ng/mL), IL-6 (100 ng/mL), and TPO (10 ng/mL); (3) 4 factors in serum-free medium (4F KSR): IMDM + 10% KSR + Flt3-L (100 ng/mL), SCF (100 ng/mL), IL-6 (100 ng/mL), and TPO (10 ng/mL); (4) 5F in serum-free medium (5F KSR): IMDM + 10% KSR + Wnt1 (20 ng/mL) + Flt3-L (100 ng/mL), SCF (100 ng/mL), IL-6 (100 ng/mL), and TPO (10 ng/mL).
Stem cell factor
promotes in vitro ovarian follicle development in the domestic cat by upregulating c-kit mRNA expression and stimulating the phosphatidylinositol 3-kinase/AKT pathway.
Gebhardt et al., "Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor
, IL-3, IL-4, and nerve growth factor," Journal of Immunology, vol.
Brehm, "Improved B cell development in humanized NOD-scid IL2R[gamma]null mice transgenically expressing human stem cell factor
, granulocyte-macrophage colony-stimulating factor and interleukin-3," Immunity, Inflammation and Disease, vol.
Lately, stem cell factor
and c-kit system was postulated to be involved in the initial activation of stem cells in the liver, and the c-Kit(+) cells were increased in portal tracts of cirrhotic patients, suggesting that c-kit(+) cells may be the progenitor cells of the liver (1,8,9).
The activation of the receptor tyrosine kinase (RTK) cKit by its ligand the stem cell factor
(SCF) induces intracellular signalling pathways which are critical to melanocyte development and migration during embryogenesis and, later, postdevelopmentally, to the regulation of melanocyte proliferation, differentiation, and survival as well as for mediation of melanin biosynthesis [16-18].
Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor
(SCF)/kit ligand (KL) in long term culture.
Stem cell factor
functions as a survival factor for mature Leydig cells and a growth factor for precursor Leydig cells after ethylene dimethane sulfonate treatment: implication of a role of the stem cell factor/ c-Kit system in Leydig cell development.
In vitro propagation of human SSCs has been reported with small pieces of normal human testis,13 as well as small testicular biopsies from azoospermic and non- obstructive azoospermic (NOA) patients with a number of important growth factors, including stem cell factor
(SCF), leukaemia inhibitory factor (LIF), glial cell-derived neurotrophic factor (GDNF), basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) in different culture systems.
The stem cell factor
SOX2 regulates the tumorigenic potential in human gastric cancer cells.
The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor