From the standpoint of nanomedicine, the antibody in ADC structure acts as a self-targeting nanoscale carrier (1-3), thus, it could overcome the issues associated with nanomedicines based on synthetic nanomaterials such as cellular internalization, clearance, sterical
hindering of binding to the epitopes and failing to release into targeted cells (4).
This can be accomplished by the bulk molecular imprinting approach in which the template molecule provides the sterical
and chemical qualities as well as the diffusion path for the subsequent recognition of the analytes .
 studied the sterical
and electrostatic stability of a high suspension self-prepared CuO nanofluid, of an average particle size of 60 nm and 0.01 wt% nanoparticle concentration, without the addition of any dispersant.
The observed difference in immune-modulating capacity between the different dual TLR2/7 ligands might be explained by sterical
hindrance of ligand binding to TLR2 and TLR7 induced by the conjugation.
In the present paper, a unique combination of azimuth and zenith angle is called a sterical
These overall sterical
differences can explain the different performance of the two Sennoside stereoisomers.
On the other hand, a longer strand of a radical, such as in 5-(C11-Aminoallyl)-2'-Deoxyuridine-5'-Triphosphate, also increases the possibility of sterical
complications, which can be clearly seen in the electropherogram, where the nucleotide with that modification was virtually not recognized by the Taq-polymerase (the polymerase of A family).
The higher stability to boiling water can be ascribed to the lower reactivity of isosorbide toward esterification, trans-esterification, and hydrolysis reactions due to the sterical
hindrance of the hydroxylic groups.
The seemingly low iodine rate (13.06) for the composition of the castor oil might be due to sterical
But this New Year our collective sense of ugliness is justified as hy sterical
demands to ban hordes of swarthy foreigners from coming here are heard by a bemused outside world.
In the presence of tc, Bla activity was reduced by a factor of 2.6, indicating that the tc-bound aptamer interferes with translation of the bla mRNA, probably by sterical
hindrance of the recognition of the RBS.
The former structure is specifically designed to enhance the ligation rate by placing the thiol group in an ideal position with respect to the nitrogen, whereas the latter decreases the sterical
hindrance and enhances the acid lability of the auxiliary.