In addition, six studies described the improvement of sternalgia [30, 31, 34-36, 38], but four were excluded because of being different from the remaining two studies in scoring criteria [30, 34-36].
Sternalgia. For the improvement of sternalgia, two trials used a model of random effect for the existence of significant heterogeneity ([chi square] = 2.60, P = 0.11, [I.sup.2] = 62%) [31, 38].
However, as for the improvements of acid regurgitation, heartburn, and sternalgia, the result of metaanalysis in acid regurgitation had a similar efficacy when compared with the control groups.