23, Wickett and Ananth will teach a second full-day CEP course on "Advanced Skin Science 2019-Advanced Topics on the Epidermis and
Stratum Corneum." This course will cover topics in skin biochemistry, biophysics and molecular biology.
ENPNewswire-July 26, 2019--Kao - Effect of the
stratum corneum barrier function on cutaneous photosensitivity
Benzoyl peroxide has been shown to increase transepidermal water loss (TEWL) and deplete tocopherol levels in the
stratum corneum, while topical retinoids thin the
stratum corneum, increase epidermal fragility, and increase TEWL.
The skin's outermost layer (
stratum corneum) acts as a barrier to the external environment.
As augmented in the 500-Da rule [3], the
stratum corneum in the skin, just a few micrometers thick effectively forms a barrier and inhibited penetration of high molecules [4].
A wide spectrum of dermatophytes cause tinea corporis.1,5,6 Dermatophytes penetrate
stratum corneum through emergence of germ tubes from the arthroconidia.6 During infection process, dermatophytes degrade proteins into large peptides, which are subsequently digested into amino acids and short peptides.7 These amino acids may provide an energy source for dermatophytes.
The histological findings of skin biopsy are frequently non-characteristic thinning of the granular layer and
stratum corneum, psoriasiform hyperplasia and less common compact parakeratosis with large nuclei, subcorneum or intracorneum splitting, presence of clear cells in the upper epidermis or
stratum corneum, dyskeratosis, dermal infiltrate with neutrophils and/or eosinophils and dilated blood vessels in the superficial dermis (6).
The composition of the lipids alters with differentiation until the final unique lipid mixture in the
stratum corneum is obtained.
Though artificial membranes may have some advantages over human skin, unambiguous correlation to human
stratum corneum barrier function has yet to be fully explored, particular for finite dose applications [10].
NYT Syndicate With the cool air of fall upon most of us and winter's cold, dry winds approaching, it's time to get serious about caring for the
stratum corneum, the outermost layer of skin, the body's largest organ, which protects the vital tissues within.
In a recent study the effect of olive and sunflower seed oils on
stratum corneum integrity and cohesion was studied.
Key words: transdermal drug delivery, nano formulation, skin enhancer,
Stratum corneum
