Investigations Haemoglobin 7 gm% Total Leukocyte Count 4500 cells/[mm.sup.3] Platelets 100000 cells/[mm.sup.3] ESR 80 mm/hr C Reactive Protein positive Serum Calcium 9 mg/dL Serum Creatinine 1.8 mg/dl Serum Urea 35 mg/dl Urine Routine-Albumin 2+ Casts Red Blood Cell Casts Present Anti-Nuclear Antibody Positive Anti Streptolysin
O Positive Throat Swab Culture Positive Liver Function Tests Normal Thyroid Profile Normal
No availability of antibodies to streptolysin
and C-reactive protein levels which have been widely used for detection of acute inflammation in SI based on current Assessment of Spondylo Arthritis international Societ classification criteria and therefore lack of research of correlation with laboratory findings was a significant limitation of our study.
The Role of Iron in the Growth and Hemolysin (Streptolysin
S) Production in Streptococcus pyogenes.
Antibodies against streptokinase (ASK), streptolysin
O (ASO), and deoxyribonuclease B (anti-DNAseB) are not reliable markers for acute GABHS infection, used either alone or in combination with one another .
Virulence profile analysis of SDSE revealed that its genetic basis of disease propensity is shared with GAS, including the antiphagocytic M protein, streptolysin
S, streptokinase, and one or more pyrogenic exotoxins .
O antibody (ASO) titer was sent but came back normal at 61 I U/mL (normal range 0-330 IU/mL), arguing against GAS peritonitis.
Subsequently, the conditioned media was removed, and the cells were permeabilized with streptolysin
pyogenes have been identified in SDSE, including hemolysin, streptolysin
, exotoxin, proteinase, adhesin, streptokinase, and hyaluronic acid genes (11,18).
Kehoe, The Thiol-Activated Toxin Streptolysin
O Does Not Require a Thiol Group for Cytolytic Activity, Infect.
The majority of virulence factors found in Group G streptococci are also found in Group A streptococci (i.e., Streptococci pyogenes), including adhesions, the M protein, Streptolysin
O and Streptolysin
S, C5a peptidase, streptokinase, and various superantigens.10, These factors are shared via horizontal gene transfer from S.
Aside from M protein, some species of GCS (Table 2) can produce a surface-exposed protein (Szp), streptokinase, streptolysin
O or streptolysin
S [2, 10], and hemolysins .
While not commonly used for this indication, linezolid has also demonstrated in in vitro studies the ability to reduce Streptococcus pyogenes toxin synthesis or activity including protein M, streptolysin
O, DNase, Spe B, Spe A, and F protein [3-5].