If an isolate is susceptible to all three drugs studied, streptomycin
may be preferable, as it was the least likely to cause hearing loss, they added.
006) g/L] increased 149% with neomycin, 65% with gentamicin, 40% with tobramycin, 11% with kanamycin, 8% with amikacin, and 6% with streptomycin
(n = 5; CV <5.
Blood was collected immediately by cardiac puncture, and peripheral blood mononuclear cells (PBMCs) were isolated against a ficoll-hypaque gradient and resuspended in complete media containing 90% (vol/vol) R[micro]MI 1640, 10% FBS, 100 U/mL penicillin, and 100 [micro]g/mL streptomycin
The following test compounds wee prepared at 120 [micro]g/ml and 60 [micro]g/ml: ND-197, uranyl nitrate, polymyxin B sulfate, streptomycin
sulfate, neomycin sulfate, eythromycin and tetracycline hydrochloride.
Five of these were supplemented with streptomycin
at a dosage of 25 [micro]g/mL, and were inoculated with 0.
But the favored streptomycin
began losing its effectiveness in the 1970's because E.
8%) were resistant to isoniazid, rifampicin, streptomycin
, ethambutol, ofloxacin, capreomycin, and amikacin, respectively.
has been replaced by ethambutol as a key drug in the intensive phase of tuberculosis chemotherapy as it is less expensive and patient's compliance is better with this drug (3).
Steyger's research focuses on how drugs such as streptomycin
enter and kill hair cells, the sensory cells in the inner ear that are pivotal to hearing.
Of the 1,170 isolates that were analyzed, 93% were resistant to at least one antimicrobial agent, including ampicillin (79% of isolates), streptomycin
(56%), sulfamethoxazole (56%), tetracycline (53%), and combined trimethoprim and sulfamethoxazole (51%).
Neomycin, gentamicin, tobramycin, and paromomycin gave higher responses (442%,304%,259%, and 135%, respectively) than BSA (100%), whereas geneticin, kanamycin, streptomycin
, and dihydrostreptomycin gave lower responses (26%, 21%, 7%, and 3%, respectively; n = 5; CV <5%).
From Koch's recognition of the tubercle bacillus to Waksman's discovery of streptomycin
over thirty decades of trial and error passed; the contributions of these men to medical science remain almost obscure footnotes.