Diabetes was induced in adult rats weighing between 150-200 g by a single intra-peritoneal injection of streptozocin
(STZ, 60 mg/kg) dissolved in citrate buffer (pH 4.5) and fed normally thereafter (16).
After overnight fasting, a single injection of streptozocin
(STZ) 50 mg/kg in a freshly prepared solution of normal saline (0.9% w/v) was administered intraperitoneally to the rats to induce diabetes (Mohan et al., 2013; Tzeng et al., 2014).
was used to induce diabetes as described previously (11).
Chemotherapy with agents such as 5-FU, capecitabine, dacarbazine, oxaliplatin, streptozocin
, and temozolomide in different combinations may be used in G1 or G2 tumours when indicated.
was purchased from Sigma Chemicals USA.
Pre- and post-treatment of streptozocin
administered rats with melatonin: Effects on some hepatic enzymes of carbohydrate metabolism.
In these experiments, we successfully established a mouse model of NAFLD and diabetes using HFD and streptozocin
Several studies have researched various combinations of capecitabine and temozolomide with other established chemotherapeutic drugs, such as streptozocin
as treatment for unresectable NETs.
Vessal, "Pre- and posttreatment of streptozocin
administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism," Archives of Iranian Medicine, vol.
Various agents such as radiation, galactose, streptozocin
, and selenite can be used to experimentally induce cataract formation.
"Histochemical and biochemical effects of melatonin on pancreatic b-cells on streptozocin
treated dia etic rats" Pharmacology, 2: 1-21(2006).
Abbreviations DR: Diabetic retinopathy SOCS: Suppressor of cytokine signalling STAT: Signal transducer and activator of transcription TIMP: Tissue inhibitor matrix metalloproteinase A2M: a2-macroglobulin VEGF: Vascular endothelial growth factor MMP: Matrix metalloproteinase STZ: Streptozocin
ADCY1: Type 1 adenylyl cyclase JAK: Janus kinase NF-[kappa]B: Nuclear factor-kappa B MAPK: Mitogen-activated protein kinase ONL: Outer nuclear layer INL: Inner nuclear layer RGC: Retinal ganglion cells.