streptozotocin


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strep·to·zot·o·cin

 (strĕp′tə-zŏt′ə-sĭn)
n.
An antibiotic, C8H15N3O7, produced by an actinomycete (Streptomyces achromogenes), used primarily to treat pancreatic tumors affecting the Islets of Langerhans. Also called streptozocin.

[streptozōticus, epithet of the subspecies from which the antibiotic was isolated (strepto- + Greek zōtikos, maintaining life, pertaining to life; see gwei- in Indo-European roots) + -(my)cin.]
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Kesireddy et al., "Nephroprotective effects of a ginger extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ)-induced diabetic complications in rats," Chinese Journal of Physiology, vol.
Diabetes was induced in overnight-fasted rat groups (II and III) by a single intraperitoneal (ip) injection of streptozotocin (STZ, 50 mg/kg) dissolved in vehicle (0.9% NaCl and 5% dextrose solution), whereas rats in groups I and IV received only the vehicle.
All animals were made diabetic by intraperitoneal injection of streptozotocin (STZ) 40 mg/kg body weight, diluted in 0.05 mmol/L citrate buffer (pH 4.5), given daily for five consecutive days during first week of experiment.
Diabetes was induced by intraperitoneal injection of 65 mg/kg streptozotocin (prepared in 100 mmol/L sodium citrate buffer, pH = 4.5) [18].
In these experiments, FP15 treatment (3-10 mg/kg), a novel potent peroxynitrite decomposition catalyst, reduced the incidence of diabetes mellitus in rats subjected to multiple low doses of streptozotocin. Moreover, they reported a potential reduction in the vascular and cardiac effect of diabetes mellitus in mice [6].
To induce diabetes in rats injected intraperitoneally dissolved streptozotocin as a single dose or dose 50mg / kg on 9/0% Nacl, 100 mM sodium citrate buffer with 5/4 PH = solutions were used [6].
Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion.
Male rats (Rattus norvegicus), with free access to food and water, and weighing 180-250 g, were injected intraperitoneally with streptozotocin (STZ; 65 mg/kg) diluted in 0.1M citrate buffer (pH 4.0).
Streptozotocin (STZ) can be used to induce both Type 1 and Type 2 DM (11).
Streptozotocin (STZ) is the most widely used agent in animals to form experimental DM.