Kesireddy et al., "Nephroprotective effects of a ginger extract on cytosolic and mitochondrial enzymes against streptozotocin
(STZ)-induced diabetic complications in rats," Chinese Journal of Physiology, vol.
Diabetes was induced in overnight-fasted rat groups (II and III) by a single intraperitoneal (ip) injection of streptozotocin
(STZ, 50 mg/kg) dissolved in vehicle (0.9% NaCl and 5% dextrose solution), whereas rats in groups I and IV received only the vehicle.
After 15 min, 45 mg/kg body weight of freshly prepared streptozotocin
in 0.1 M citrate buffer (pH 4.5) was injected (Masiello et al.
All animals were made diabetic by intraperitoneal injection of streptozotocin
(STZ) 40 mg/kg body weight, diluted in 0.05 mmol/L citrate buffer (pH 4.5), given daily for five consecutive days during first week of experiment.
Diabetes was induced by intraperitoneal injection of 65 mg/kg streptozotocin
(prepared in 100 mmol/L sodium citrate buffer, pH = 4.5) .
In these experiments, FP15 treatment (3-10 mg/kg), a novel potent peroxynitrite decomposition catalyst, reduced the incidence of diabetes mellitus in rats subjected to multiple low doses of streptozotocin
. Moreover, they reported a potential reduction in the vascular and cardiac effect of diabetes mellitus in mice .
To induce diabetes in rats injected intraperitoneally dissolved streptozotocin
as a single dose or dose 50mg / kg on 9/0% Nacl, 100 mM sodium citrate buffer with 5/4 PH = solutions were used .
Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin
inhibition of insulin secretion.
Adult male Sprague Dawley rats (350-400 g) received a dose of streptozotocin
(STZ, 40 mg/kg, i.p.) within a citrate buffer (pH 5.5) on the day of use.
Male rats (Rattus norvegicus), with free access to food and water, and weighing 180-250 g, were injected intraperitoneally with streptozotocin
(STZ; 65 mg/kg) diluted in 0.1M citrate buffer (pH 4.0).
(STZ) can be used to induce both Type 1 and Type 2 DM (11).
(STZ) is the most widely used agent in animals to form experimental DM.