substantia nigra

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Related to substantia nigra: dopamine, Cranial nerves, basal ganglia, striatum

substantia ni·gra

 (nī′grə, nĭg′rə)
A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.

[New Latin : Latin substantia, substance + Latin nigra, feminine of niger, black.]

substantia nigra

(səbˈstænʃə ˈnaɪɡrə)
(Anatomy) a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease
[C20: from Latin, literally: dark material]

sub•stan•ti•a ni•gra

(səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə)

n., pl. sub•stan•ti•ae ni•grae (sʌbˈstæn ʃiˌi ˈnaɪ gri, ˈnɪg ri) substantia ni•gras.
a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.
[1880–85; < New Latin: black substance]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.substantia nigra - a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
neural structure - a structure that is part of the nervous system
mesencephalon, midbrain - the middle portion of the brain
References in periodicals archive ?
Research has confirmed that symptoms of PD are a result of progressive dopaminergic cell death in the substantia nigra pars compacta of the basal ganglia (Bergman & Deuschl, 2002).
The loss of dopaminergic neurons in PD is evident through the loss of the substantia nigra in the basal ganglia.
Pick bodies were also present in temporal and parietal cortex, caudate and putamen, substantia nigra, locus coeruleus, and pontine nuclei (not shown).
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the degeneration and progressive loss of dopaminergic neurons in the substantia nigra pars compacta.
Dorsal striatum: A pair of nuclear masses that form the basal ganglia, along with the subthalamic nucleus and the substantia nigra.
A year later, we demonstrated that parkin was produced in the substantia nigra and localized in Lewy bodies (4).
In brains only the CB1 receptor can be found in high densities, especially in the hippocampus and the substantia nigra (Matsuda et al.
The focus is on how the interplay between glutamate and dopamine, particularly at the level of medium spiny neurons in the striatum and at the level of output from the substantia nigra, contributes to the fine-tuning of analogue inhibitory signaling through the basal ganglia.
Dopamine relays messages between the substantia nigra and other parts of the brain to control movements of the human body, helping humans to have smooth, coordinated muscle movements.
A: Parkinson's disease (PD) is a serious and common progressive neurological condition resulting from a loss of brain cells in a specific location, the substantia nigra.
PD occurs when the neurons that produce dopamine, found in the substantia nigra of the human brain, slowly degenerate and result in a lack of the neurotransmitter dopamine.
Rather than beginning in the substantia nigra and moving into the cerebellar regions, nerve damage may begin in the dorsal motor nucleus of the vagal nerve and progress upward into the midbrain, killing neurons all along its path.

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