substantia nigra

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Related to substantia nigra: dopamine, Cranial nerves, basal ganglia, striatum

substantia ni·gra

 (nī′grə, nĭg′rə)
A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.

[New Latin : Latin substantia, substance + Latin nigra, feminine of niger, black.]

substantia nigra

(səbˈstænʃə ˈnaɪɡrə)
(Anatomy) a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease
[C20: from Latin, literally: dark material]

sub•stan•ti•a ni•gra

(səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə)

n., pl. sub•stan•ti•ae ni•grae (sʌbˈstæn ʃiˌi ˈnaɪ gri, ˈnɪg ri) substantia ni•gras.
a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.
[1880–85; < New Latin: black substance]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.substantia nigra - a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
neural structure - a structure that is part of the nervous system
mesencephalon, midbrain - the middle portion of the brain
References in periodicals archive ?
Interestingly, SMAD1 is required for the development of particular substantia nigra neurons, which predominantly degenerate in Parkinson's disease, shedding light on the vulnerability of this subset of dopaminergic neurons.
The triggering factor in the pathogenesis includes the progressive loss of dopaminergic neurons of substantia nigra pars compacta.
Background: Numerous studies have demonstrated that patients with Parkinson's disease (PD) have a higher prevalence of substantia nigra (SN) hyperechogenicity compared with controls.
Editor's Note: "Parkinson's disease occurs when dopaminergic neurons in a part of the brain called the substantia nigra are lost," Dr.
The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain.
The human midbrain is of particular interest to Parkinson's researchers: it is the seat of the tissue structure known as the substantia nigra.
Therapeutic solutions company BIAL reported on Thursday the launch of an exclusive licensing agreement for the development and commercialisation of its opicapone in North America with Neurocrine Biosciences Inc (NasdaqGS:NBIX) for the treatment of adult patients with Parkinson's disease, a chronic and progressive movement disorder that is characterized by a loss of neurons in the substantia nigra, the area of the brain where dopamine is produced.
The inflammatory cells of the central nervous system are activated in the substantia nigra and basal ganglia, the impaired areas of the brain in PD patients.
A higher expression of [alpha]-synuclein in the substantia nigra compared with control samples (16% vs 0%) even in asymptomatic patients was found, suggesting a relation between these neurotoxic mechanisms and the physiopathology of PD and other neurodegenerative diseases.
This troublesome duo, with its resulting chemical products, is particularly dangerous in the substantia nigra, the dopamine-rich part of the brain damaged in Parkinson's, Hare, of the University of Technology Sydney, and Double, of the University of Sydney, propose.
It is associated with old age, and characterized by the loss of neurons in the substantia nigra region of the brain.

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