Viral mRNA is also used as the first strand and template for the synthesis of the second strand of viral genomic RNA; the newly replicated genome is retained in an inner capsid structure called subviral
particles (Lemay 1988).
The compounds under investigation, REP 2139-Mg or REP 2165-Mg used in combination with tenofovir and PEG-IFNa and given by intravenous infusion, block the entry and formation of subviral
particles by interfering with apolipoprotein-HBsAg interactions.
The self-assembling feature of these proteins results in the generation of subviral
or viral particles in the 20-100 nm size range, typically (Ghasparian et al.
agents associated with plant single-stranded DNA viruses.
They explain infections and syndromes related to specific organ systems, as well as the fundamentals of modern medical virology, including immune responses and vaccinology, diagnostics, and antivirals, then agent-specific chapters on the virology, epidemiology, pathogenesis, clinical manifestations, laboratory diagnosis, and prevention and treatment of key viral pathogens: specific DNA viruses, RNA viruses, and subviral
These results are not surprising because serum HBsAg is produced not only from transcriptionally active cccDNA, but also from integrated HBV DNA sequences.[sup] Serum HBsAg particles in the peripheral blood are found in two forms: virion-associated HBsAg and empty HBsAg subviral
particles, with a much lower proportion of the former than the latter.[sup]
A novel subviral
agent associated with a geminivirus: The first report of a DNA satellite.
They produce subviral
particles; generate persistent infection and replicate through RNA intermediate via reverse
Hepatitis B virus subviral
envelope particle morphogenesis and intracellular trafficking.
D., Torres, V., Pons, F 1993 Method combining inmunocapture and PCR amplication in a microtite plate for the detection of plant viruses and subviral
pathogens Journal of Virological Methods 45: 201-218