In general, particles are classified as subvisible
up to a size of 100 micron.
particles in therapeutic protein products: gaps that may compromise product quality.
With regards to providing solutions to existing problems, industry still has a lot of room to improve including lowering visible and subvisible
particulates, controlling and/or eliminating silicone oil and providing viable solutions for the growing compounding pharmacy market."
At the same time, there remains a thread of interest in the "subvisible
" or "hidden" nature of form, even if that "hidden" nature is often resolutely de-idealized.
Every year, numerous injectable/parenteral drugs are recalled from the market due to the presence of visible and subvisible
Long term safety, high-resolution imaging, and tissue temperature modeling of subvisible
diode micropulse photocoagulation for retinovascuclar macular edema.
(2015) showed that the frequency of subvisible
cirrus (SVC) in south India has increased by 9% from 1998 to 2013, with possible connections with the positive trend in ATAL's AOD since the late 1990s (Vernier et al.
Wang et al., "Subvisible
retinal laser therapy: titration algorithm and tissue response," Retina, vol.
Schoeberl, "On the formation and persistence of subvisible
cirrus clouds near the tropical tropopause," Journal of Geophysical Research Atmospheres, vol.
Issues with glass delamination and the generation of both visible and subvisible
flakes and particulates in marketed drug products have increased significantly within the last several years, leading to numerous recalls.
Examples include counting and sizing of subvisible
particulate matter per USP Chapter (788)  or per European Pharmacopoeia 2.9.19  and measuring the concentrations of larger sized globules in nutritional emulsions per USP Chapter (729) .