'Earlier in April, we initiated the global ATTACK (Acinetobacter Treatment Trial Against Colistin) Phase 3 pivotal trial evaluating a fixed-dose combination of sulbactam
plus durlobactam, or SUL-DUR (ETX2514SUL), as a potential treatment for carbapenem-resistant Acinetobacter baumannii infections.
Preseptal and orbital cellulitis: 15-year experience with sulbactam
coli isolates, the sensitivity pattern towards, Cefepime Tazobactam was 90%, Cefepime--32%, Piperacillin Tazobactam -75%, Cefoperazone sulbactam
71%, Carbapenem- 91%, and Amikacin- 92%.
The prime objective of this study was to evaluate safety and efficacy of Cefoperazone + Sulbactam
(CPS) and Cefotaxime + Sulbactam
(CTS) combinations used in the treatment of complicated UTI.
Resistance for other antibiotics such as sulbactam
ampicillin 22 (68.8%), Doxycycline 14 (43.8%), cefipime 31 (96.9%), minocycline 11 (34.4%), tazobactam piperacillin 26 (81.3%), ciprofloxacin 31 (96.1%), gentamicin 20 (62.5%), amikacin 16 (50%), trimethoprim-sulfamethoxazole 28 (87.5%), Meropenem 23 (71.9%) and Imepenem 25 (78.1%) was found.
Petromax (b) (Amoxycillin and Sulbactam
) @ 20mg/kg b.
To date, colistin (polymyxin E) or polymyxin B-based combinations are recommended as treatments for CRAB because almost all strains of CRAB remain sensitive to polymyxins , while sulbactam
and fosfomycin have better pharmacokinetic profiles with moderate and low protein binding.
Other antibiotics tested were: imipenem, meropenem, tazobactum, amikacin, cefoperazone sulbactam
, gentamicin, cefepime, ceftazidime, co-amoxiclav, ticarcillin, aztreonam, cefoperazone, co-trimoxazole, cefotaxime, cefixime, ceftriaxone, pipemidic acid and ampicillin.
ETX2514 exhibited particularly promising activity in combination with sulbactam
against Acinetobacter baumannii, including hard-to-treat carbapenem-resistant and colistin-resistant strains, and with imipenem against carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa.
baumannii (MIC[sub]90 64–128 mg/L), in which activity is due to sulbactam
alone [Table 2].