All protons enter resonance in suitable positions, ie OH group in LH gives a large singlet at 14.04 ppm, singlet at 8.92 ppm (CH=N), aromatic ring linked to 7.02-7.45 ppm sulfapyridine
, aromatic protons of hydroxynaphthalene ring at 7.50 - 8.52 ppm, and 2.52 ppm for the methyl group.
The research group of Hu was developed a ZnS QDs/MIP-based fluorescence nanosensor for the sensitive detection of sulfapyridine
in tap water samples .
Figure 3 shows the comparison between: i) sulfapyridine
and sulfadiazine (difference in one nitrogen atom in the heterocyclic moiety), ii) sulfadiazine and sulfisomidine (difference in two methyl groups and in the position of the two nitrogen atoms in the heterocyclic moiety), and iii) sulfamethizole and sulfamethoxazole (difference in one nitrogen atom and the change of a sulfur atom by oxygen atom in the heterocyclic moiety).
In order to differentiate the anti-inflammatory mechanism of action of 5-ASA from sulfasalazine, which contains one molecule of 5-ASA coupled to one molecule of sulfapyridine
via an azo bond, we separately tested the acute effects of sulfapyridine
in the toxin A model of rat colitis.
The compound is used to denature alcohols such as ethanol and in the synthesis of sulfapyridine
, antihistaminic drugs (tripelennamine and mepyramine), and in in vitro synthesis of DNA.
Sulfasalazine is a pro-drug of 5-ASA linked to sulfapyridine
, which allows passage to the colon.
In this research, the ability of statistical methods has been used in the separation of the overlapped electrochemical peaks created by two important biomedicines, including sulfamethoxazole and sulfapyridine
Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine
. Redox Report 15, 259-267.
(1) Second-line treatments--such as dapsone, sulfapyridine
, mycophenolate mofetil, administered alone or concurrently with steroids--may be considered for those who fail to respond to conventional treatment.
Other accepted treatments for LABD are dapsone, sulfonamides (sulfapyridine
and sulfamethoxypyridazine), colchicine, and topical and oral corticosteroids [1-4,12].