sulfinpyrazone


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sul·fin·pyr·a·zone

 (sŭl′fĭn-pĭr′ə-zōn′)
n.
A drug, C23H20N2O3S, related to phenylbutazone, that promotes urinary excretion of uric acid and is used in the treatment of gout.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
"A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened Stroke." New England Journal of Medicine, 299(July): 53-59.
Following loading, the cells were washed twice with Ca[Cl.sub.2]- deprived KRH and re-suspended in Ca[Cl.sub.2]-free KRH supplemented with 250 mM sulfinpyrazone to prevent dye leakage.
The pharmacologic treatment of acute gout attacks may use non-steroidal anti-inflammatory drugs, colchicine or corticoids, while chronic therapy uses inhibitors of the uric acid synthesis (allopurinol or febuxostat), uricosuric drugs that favour the elimination of the uric acid (probenecid, benziodarone or sulfinpyrazone) or uricase derivatives (rasburicase, pegloticase).
In Brazil, sales are permitted by the Brazilian Health Surveillance Agency (ANVISA) and benzbromarone seems to have a safety profile identical to sulfinpyrazone [14].
Miners, "Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human UDP-glucuronosyltransferases," Drug Metabolism and Disposition, vol.
The formation of uric acid from purines may be reduced with xanthine-oxidase inhibitors allopurinol or febuxostat, or the use of uricosuric drug sulfinpyrazone to increase the excretion of uric acid within urine.
A sixth agent, sulfinpyrazone (Anturane), a uricosuric agent, has been withdrawn from the market, but there are no reports describing its use to treat gout in pregnant women.
Myers, Cairns, and Singer examined gastrointestinal side effects in a multicenter trial of aspirin or sulfinpyrazone in the treatment of unstable angina.
(28) This protein is the target for most uricosuric drugs, including probenecid, sulfinpyrazone, benzbromarone, and high-dose salicylates, as well as minor uricosurics, such as losartan.
Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.
Sulfinpyrazone, propranolol, ranitidine, salbutamol, enalapril and lovastatin are some of the precedents spanning this time period." Apotex v.
In addition to aspirin, sulfinpyrazone and ticlopidine were included in the analysis of related drugs.