For the study, the researchers separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac
, an anti-inflammatory drug.
Photoprotective effects of sulindac
against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice.
For the animal study, they separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac
, an anti-inflammatory drug, which was chosen because a previous study showed it significantly reduced the number of tumors in humans.
g) lbuprofen, aceclofenac, acemetacin, dexibuprofen, dexketoprofen, diclofenac sodium, diflunisal, etodolac, fenbufen, fenoprofen, flurbiprofen, ibuprofen, indometacin, ketoprofen, mefenamic acid, meloxicam, nabumetone, naproxen, piroxicam, sulindac
, tenoxicam, tiaprofenic acid, diclofenac/misoprostol.
Nonsteroidal anti-inflammatory drugs (NSAIDs), other than sulindac
, could increase serum lithium levels.
5) In 2012, Castelsague, et al, conducted a meta-analysis of 28 studies and found that naproxen (relative risk 4-5) has a higher risk of gastrointestinal events when compared to aceclofenac, celecoxib and ibuprofen (RR<2), and rofecoxib, sulindac
, diclofenac, meloxicam, nimesulide and ketoprofen (RR= 2<X< 4).
Although all NSAIDs can affect kidney function, NSAIDs with a quick onset and short half-life, such as ibuprofen, can exhibit nephrotoxic effects in a matter of days compared to NSAIDs with a longer half-life, like piroxicam and sulindac
Loss of GDF-15 abolishes sulindac
chemo-prevention in the ApcMin/+ mouse model of intestinal cancer.
Difluoromethylornithine plus sulindac
for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial," Cancer Prevention Research, vol.
Non-steroidal anti-inflammatory agents: phenylbutazone, indomethacin, ibuprofen, sulindac
Combination treatment with arsenic trioxide and sulindac
augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction.
NSAID classification Non-selective inhibition Acetic acid Proprionic acid Fenamate derivatives derivatives derivatives * Diclofenac * Fenoprofen * Meclofenamate * Etodolac * Flurbiprofen * Mefenamic acid * Indomethacin * Ibuprofen * Sulindac
* Ketoprofen * Tolmetin * Naproxen * Oxaprozin Naphthyl alkanone Salicylates * Nabumetone * Aspirin * Diflunisal * Choline magnesium trisalicylate * Salicylate Enolic acid derivatives * Piroxicam * Meloxicam Selective COX-2 inhibition * Celecoxib * Rofecoxib Table 9.