sulphanilamide

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Related to sulphanilamides: Sulfanilamides

sulphanilamide

(ˌsʌlfəˈnɪləˌmaɪd)
n
(Elements & Compounds) a white odourless crystalline compound formerly used in medicine in the treatment of bacterial infections. Formula: NH2C6H4SO2NH2. See also sulfa drug
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Sulphanilamides, naphthalaminediamine HCl, phosphoric acid was obtained from Loba Chemie Pvt.
Fujie and Ogawa [44] determined sulphanilamide by thermometric titrations.
A method of quantitative determination of sulphanilamide by reaction with p-dimethylaminocinnamic aldehyde [48] in acid medium has been suggested.
Prasad et al [53] determined sulphanilamide, sulphapyridine, sulphaguanidine, sulphathiazole, sulphamerazine and sulphadiazine by titration with KBr[O.sub.3] the end point being indicated by a biamperometric system with Pt-graphite electrode.
Indirect flow injection voltammetric determination of sulphanilamide by monitoring at a glassy carbon electrode the excess of nitrite remaining after its diazotization has been reported by Fogg et a1 [55].
A stock solution of sulphanilamide, sulphapyridine, sulphathiazole and sulphadiazinc (Sigma Chemicals, USA; May and Baker Ltd, England) was prepared by dissolving known amount (-500mg) of the sample in minimum quantity of 0.05 N NaOH in a 500 ml volumetric flask and then the solution was made up to the mark with distilled water.
Invoking the validity of the reaction towards quantitation, aliquots containing different amounts of the sulphanilamide test sample were allowed to react with varying volumes of Copper(III) reagent by boiling on a hot plate for different intervals of reaction-time.
Aliquots containing 1 mg of the sample (sulphanilamide) were taken in 100 ml Erlnmeyer flasks and known excess of Cu(III) reagent was added.
It was observed that the recovery of sulphanilamide became constant within 15 minutes (Table 2).
Keeping reaction-time, amount of sulphanilamide and reaction, temperature as constant, the effect of varying volume of Cu(III) reagent was studied.
One mole of sulphanilamide consumes 6 moles of Cu(III) reagent and the amino group gets oxidized to corresponding nitrogroup.