sulphatase


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sulphatase

(ˈsʌlfəˌteɪz)
n
an enzyme of the esterase group that catalyses the hydrolysis of sulphate esters
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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In the beginning of tibolon use, it was considered that tibolon could absolutely protect the breast tissue from proliferation, due to inhibitory action of its metabolites on sulphatase, the consequence is inhibited conversion of estrone sulfate to estradiol.
2011 the activities of [beta]-glucosidase, phosphatase, sulphatase, and FDA were 2.0; 3.8 and 3.6 times higher, respectively, than in Oct.
McCune Albright syndrome may lead to pituitary micro or macroadenomas and related excessive secretion of GH and/or prolactin, acromegaly due to severe FD, unilateral or bilateral macroorchidism and rarely a clinical picture of precocious puberty secondary to sulphatase activity.
Other causative factors may include constipation, female gender, the presence of bacteria containing sulphatase and phosphatase enzymes, and alkaline urine.
The vitamin D receptor-mediated activation of phosphatidylinositol 3-kinase (PI3Kalpha) plays a role in the 1alpha,25-dihydroxyvitamin D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines.
Phenolics and flavonoids are inhibitors of decomposition processes including enzymatic activities (sulphatase, phosphatase, [beta]-glucosidase, xylosidase, chitinase, and dehydrogenase) and are also involved in stabilization of xenobiotics and Fe complexation representing a potential constraint in wetland-based acid mine drainage bioremediation, due to low Fe availability (e.g., [43, 44]).
In presence of a sulphatase producing organism, the urinary bacteria break down the indoxyl sulphate to indoxyl via sulphatase enzyme.
Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma.
Ghilchik et al., "Regulation of steroid sulphatase expression and activity in breast cancer," Journal of Steroid Biochemistry and Molecular Biology, vol.
Two forms are recognised: Type A, a deficiency of the enzyme galactosamine-6 sulphatase; and Type B, a deficiency of the enzyme beta-galactosidase.