Coluccia, An in-silico approach aimed to clarify the role of Y181C and K103N HIV-1 reverse transcriptase mutations versus Indole Aryl Sulphones
Experimental results suggested that for in situ application of dichlorotriazine dye and sulphatoethyl sulphones
agents, temperature of dye bath should beat70 [degree]C, and pH should be 6.0-6.5 using phosphate buffer with reaction time of 1 h, however, reaction period of 2 and 4 h were also measured.
Although infantile acropustulosis responds well to sulphones
like dapsone12 but due to its potential side effects, the exact treatment still remains controversial13.
Various drugs that decrease the immune reactivity are used to treat PG, of which first line are oral corticosteroids, dapsone and sulphones
. Second line are other immune-suppresants and biologicals.
The introduction of effective antimicrobial treatment for leprosy, first with the sulphones
by Faget (1) in 1943, was the major scientific development of the twentieth century to actually alter disease course and provide patients reason to hope.
Peptidyl vinyl sulphones
: a new class of potent and selective cysteine protease inhibitors.
sulphonamides and sulphones
) inhibitors; and (iii) sesquiterpenes (artemisinin and its derivatives) (4).
Agents * that may cause haemolytic anaemia in G6PD deficiency * Antimalarials: primaquine, chloroquine, sulfadoxine-pyrimethamine * Sulphonamides and sulphones
: co-trimoxazole, dapsone, salazopyrin * Other antibacterials: nalidixic acid, nitrofurantoin, chloramphenicol * Analgesics: aspirin (high doses) * Miscellaneous: vitamin K analogues, naphthalene (mothballs and henna), probenecid, methylene blue * Fava beans * Disclaimer--the lists provided are examples of commonly used drugs and are not inclusive of all drugs reported to cause haemolytic anaemia.
The heteroatoms (N, O, S) are present as carboxylic acids, carbonyl, phenol, pyrroles, pyridine, thiol, thiophene and sulphones
while the metals (Ni and V) are mostly present as organometallic compounds (Gawrys et al., 2002).
Bacterial pathogens bearing acquired metallo-[beta]-lactamase (MBL) genes exhibit a broad-spectrum resistance to [beta]-lactams that is not reversible by serine-[beta]-lactamase inhibitors (e.g., clavulanate and penicillanic acid sulphones
), sincc MBLs are capable of hydrolyzing most [beta]-lactams and are not susceptible to inhibitors.
Chemotherapy for leprosy has been available since the 1940s but early hopes that the sulphones
would control and perhaps eventually eradicate leprosy proved in vain.
For these unfortunate sufferers, the situation became hopeful with the introduction of sulphones
in the 1940s and still more encouraging after the introduction of MDT in 1981 and it actually brightened when the World Health Assembly in 1991 adopted a resolution for its Global elimination by the year 2000.