Efficacy of glucose-lowering therapies* Class Reduction in [Hb.sub.A1c] Agents Biguanides 1.0 - 2.0 Metformin Sulphonylureas
1.0 - 2.0 Glibenclamide, gliclazide Insulin 1.5 - 3.5 Thiazolidinedione 0.5 - 1.4 Pioglitazone GLP-1 agonist 0.5 - 1.0 Exenatide DPP4-inhibitor 0.5 - 0.8 Sitagliptin, vildagliptin Glinide 0.5 - 1.5 Repaglinide Amylin analogue 0.5 - 1.0 Pramlintide *Adapted from Nathan D et al.
In the West Midlands around 1,850 children have diabetes -of these 1,788 have Type 1 diabetes PEOPLE with diabetes can - and do - take part in most sports and activities apart from piloting a plane, scuba diving or a lone parachute jump (if your diabetes is treated with insulin or sulphonylureas
London, Dec 4 (ANI): Sulphonylureas
, a type of drug widely used to treat type 2 diabetes, has a greater risk of causing heart failure and death as compared to metformin, another popular antidiabetes drug, according to a study.
The study, funded by health charity Diabetes UK, shows that people with Type 2 diabetes and the gene variants who take diabetic drugs known as sulphonylureas
may be less likely to develop diabetes complications such as heart disease, kidney disease and stroke.
of target organs damaged ([+ or -] SD) 1.4 [+ or -] 1.3 1.7 [+ or -] 1.2 Drugs used (N (%)) Metformin 32 (68%) 32 (63%) Sulphonylureas
18 (38%) 16 (31%) Insulin 37 (79%) 39 (76%) Aspirin 36 (77%) 32 (63%) Statin 18 (38%) 17 (33%) ACE inhibitors 36 (77%) 28 (71%) Age (mean [+ or -] SD) NS Years of education (mean [+ or -] SD) [HBAI.sub.tc] <7.0% NS [HBAI.sub.tc] [greater than or equal to] 7.0% p=0.013 Diabetic control (N (%)) [HBAI.sub.tc] <7.0% p=0.019 [HBAI.sub.tc] [greater than or equal to] 7.0% Patient reported adherence (N (%)) Dietary NS Medication NS Mean No.
The medication information pad contains tear sheets with details on the prescription drugs Metformin, Glitazones, Acarbose, and Sulphonylureas
. The patient log book provides a place for patients to keep a track of their blood glucose monitoring.
Examples of some kinds of tablets for diabetes are metformin, sulphonylureas
The major classes of synthetic oral hypoglycemic agents currently available for the management and/or control of adult-onset, NIDDM, type-2 diabetes mellitus include the sulphonylureas
, biguanides, thiazolidinediones, alpha-glucosidase inhibitors, and so forth.
Effects of diet, sulphonylureas
, insulin or biguanide therapy on fasting plasma glucose and body weight over one year.
They may also explain why too aggressive lowering of blood glucose in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was associated with increased mortality  and why agents such as sulphonylureas
[22, 23]and insulin  which are prone to cause hypoglycaemia have also been associated with increased mortality and cardiovascular events by some authors.
: which are the next cost effective group of anti-diabetic drugs of which the most economical one is glibenclamide the cost of a day's treatment of which is Rs.
Many patients can be successfully treated with oral sulphonylureas
rather than insulin.16 Sulphonylureas
have affinity to SUR1 and stimulate insulin secretion by an ATP-independent mechanism and can successfully replace insulin therapy to achieve a better metabolic control.9 The effectiveness of oral sulfonylurea in improving glyceamic control of diabetic patients due to KCNJ11 mutations after transfer from insulin therapy has been confirmed by many reports16 but a molecular diagnosis is required before the use of sulfonylurea therapy in neonatal diabetes is considered.17