The nature of the circadian periodicity and suppressibility
of immunoreactive ACTH levels in Addison's disease.
The first diagnostic dilemma in this case was that the initial laboratory data suggested Cushing's Disease since the patient had an elevated ACTH and dexamethasone suppressibility. However, pituitary MRI was negative and inferior petrosal sampling did not show a central to peripheral ACTH gradient.
Since BPC is the most common cause of ectopic ACTH secretion, (1,8,10) and since these tumors may show suppressibility in response to dexamethasone, a bronchoscopy was empirically done.
of cortisol after dexamethasone is a sensitive test to assess the integrity of HPA axis (13-14) and more than one third of the patients had non-suppresible cortisol in this study.
In contrast, addition of KTZ, which was added to demonstrate suppressibility
of testosterone production, failed to consistently induce such a decrease over a 48-hr culture period compared with basal levels of testosterone production (Figure 3).
Confirmation of the condition was established by impaired suppressibility
of cortisol secretion by dexamethasone and increased excretion of cortisol in the urine.
While this cycle of relative suppressibility
and release is characteristic of tics in TS, it can lead to confusion and misguided attempts on the part of parents and teachers to use discipline or conditioning to stop the tics (Packer, 1997).
Serum thyroid-stimulating antibody, thyroglobulin levels, and thyroid suppressibility
measurement as predictors of the outcome of combined methimazole and triiodothyronine therapy in Graves' disease.
Confirmatory testing was done by means of volume expansion, using a 3-day high-salt diet to assess the suppressibility
of the 2f1-f2 stimulated acoustic emissions in gerbil and man.
of cortisol after high dose dexamethasone had been shown in slowly growing bronchial carcinoids thereby rendering them difficult to differentiate from pituitary Cushing's disease (26).
Only subjects with plasma cortisol within the reference values at 800, 1700, and 2400, cortisol circadian rhythm with suppressibility
by 1 mg of dexamethasone overnight, and normal inflammatory indexes and blood chemistry were included in the study.