suppressor T cell

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suppressor T cell

n.
A T cell that reduces or suppresses the immune response of B cells or of other T cells to an antigen.

suppressor T cell



n.
a T cell capable of inhibiting the activity of B cells and other T cells.
Also called T suppressor cell.
References in periodicals archive ?
The Company's immuno-regulatory product candidates include ProTmune, a pharmacologically modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders.
But surgery causes another kind of immune cell called MDSC (myeloid derived suppressor cell) to block the NK cells.
MDSC: Myeloid-derived suppressor cell M-MDSC: Monocytic MDSC G-MDSC: Granulocytic MDSC DC: Dendritic cell HR1: Histamine receptor 1 BCL-XL: B-cell lymphoma XL TLR: Toll-like receptor ADAM: A disintegrin and metalloproteinase miRNA: MicroRNAs ROS: Reactive oxygen species MEF2C: Myeloid enhancement factor 2C Arg-1: Arginase-1 Treg: Regulatory T cell SCLC: Small cell lung cancer NSCLC: Nonsmall cell lung cancer SWCNT: Single-walled carbon nanotubes ATRA: All-trans-retinoic acid SCF: Stem cell factor VEGF: Vascular endothelial growth factor COX2: Cyclooxygenase 2 EMT: Epithelial mesenchymal transition.
Abbreviations CAFs: Cancer-associated fibroblasts CSCs: Cancer stem cells CTSB: Cathepsin B COX-2: Cyclooxygenase-2 EGF: Epidermal growth factor EMT: Epithelial-to-mesenchymal transition ECM: Extracellular matrix bFGF: fibroblast growth factor G-CSF: Granulocyte colony-stimulating factor HGF: Hepatocyte growth factor HIF: Hypoxia-inducible factor HRE: Hypoxia-regulated element iNOS: Inducible nitric oxide synthase IGF: Insulin-like growth factor IL: Interleukin MCs: Mast cells MDSC: Myeloid-derived suppressor cell NK: Natural killer PDGF: Platelet-derived growth factor PD-L1: Programmed death-ligand 1 PGE2: Prostaglandin ROS: Reactive oxygen species SDF-1: Stromal-derived factor 1 TGF-[beta]: Transforming growth factor beta VEGF: Vascular endothelial growth factor.
Kelso et al., "Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function" Journal of Experimental Medicine, vol.
Deficient [CD8.sup.+] [CD28.sup.-] T-suppressor cell function was noted during MS attacks with suppressor cell function restored during remissions.
Ash from burned residual oil, a viscous boiler fuel, proved even more potent at triggering suppressor cell suicides.
It was just over 10 years ago that people with multiple sclerosis were first discovered to be deficient in their suppressor cell function compared with healthy people.
The Company's immuno-regulatory product candidates include ProTmune, a pharmacologically-modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders.
CBI has also advanced the development of a novel immuno-prognostic bioassay that measures a critical immune suppressor cell population found in blood samples of cancer patients.
Marigo et al., "Myeloid-derived suppressor cell heterogeneity and subset definition," Current Opinion in Immunology, vol.