suppressor gene

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Related to suppressor gene: lethal gene, suppressor mutation
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Noun1.suppressor gene - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
gène suppresseur
References in periodicals archive ?
Jude Childrens Research Hospital found germline variations in a key tumor suppressor gene that may prompt changes in treatment and follow-up care for certain high-risk leukemia patients.
BRCA1 is a class of genes known as tumour suppressor genes because they normally act to restrain the growth of cells in the breast, while BRCA2 is a tumour suppressor gene that is found in all humans.
The best known tumour suppressor gene is likely p53, also known as the guardian of the genome.
The tumour suppressor gene p53-mutated approximately in 70% of adult solid tumours.
It appears to play a fundamental role in the operation of the p53 tumor suppressor gene, which is a focus of much modern cancer research.
Laiho's research linked the pathway to p53 gene activity; p53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.
According to the company, SGI-110 is a small molecule, DNA-hypomethyating agent with demonstrated activity in restoring silenced tumour suppressor gene expression in cancer cells by reversal of DNA methylation.
Knudson postulated that, for the o onset of a neoplasia, both alleles of a tumor suppressor gene should mutate.
HCC often harbors a TP53 tumor suppressor gene mutation at codon 249 (R249S).
Four years ago, we started to profile molecular markers genes for cancer patients and at the beginning with the oncogene tumor suppressor gene P53, whose critical role is evident by the fact that it is mutated in approximately 50% to 70% of all human cancer.
When the researchers measured cells in breast milk from 13 women who turned out to have cancer, these cells had substantially more methylation in a tumor suppressor gene called RASSF1 than did cells from the noncancerous breast.