Phentermine, a sympathomimetic amine
approved for short-term weight loss, has been marketed in the United States since 1959; topiramate, an antiseizure medication, was approved for treating adult epilepsy in 1996, migraine prophylaxis in 2004, and pediatric epilepsy in 2011.
The product contains an immediate-release formulation of phentermine (a sympathomimetic amine
approved for short-term weight loss that has been marketed in the United States since 1959), and a controlled-release formulation of topiramate (approved for treating adult epilepsy, migraine prophylaxis, and pediatric epilepsy).
Ephedrine (EP) is a sympathomimetic amine
commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
Mephentermine is a sympathomimetic amine
that acts directly as well as indirectly via an action on [alpha]- and [beta]-adrenergic receptors.
Medications Used for Weight Loss Drug Mechanism of action Side effects Orlistat * Lipase inhibitor Diarrhea, flatulence, (Xenical) Decreases fat absorption bloating, abdominal pain, dyspepsia Sibutramine * Appetite suppressant; Modest increases in heart ([dagger]) Norepinephrine and rate and blood pressure; (Meridia) serotonin reuptake nervousness, insomnia inhibitor Diethylpropion * Appetite suppressant: Palpitations, ([dagger]) sympathomimetic amine
tachycardia; insomnia, gastrointestinal Phentermine * Appetite suppressant: Cardiovascular, ([dagger]) sympathomimetic amine
gastrointestinal * Approved by FDA for weight loss ([dagger]) Drug Enforcement Administration Schedule IV Source: Annals of Internal Medicine 2005; 142 (7) 525-31
For the most part, women in our study were taking aspirin for cold symptoms, which raises the possibility that it may be the cold, not the aspirin or sympathomimetic amine
, that causes the malformation.
Like Fentluramine, Phentermine is a sympathomimetic amine
with pharmacologic activity similar to amphetamines.
The combination product contains an immediate-release formulation of phentermine, which is a sympathomimetic amine
approved for short-term weight loss, on the market in the United States since 1959; and a controlled-release formulation of topiramate, an antiepileptic drug approved for treating epilepsy in 1996, for migraine prophylaxis in 2004, and for pediatric epilepsy in 2011.
Mephentermine, a sympathomimetic amine
having [alpha]- and [beta]-adrenergic agonist actions, is commonly used in India as a vasopressor for prevention and treatment of hypotension following spinal anaesthesia.
Thin-layer chromatography, performed the next day as part of the comprehensive drug screen, identified the sympathomimetic amine
as PPA and also picked up the presence of acetaminophen.