synaptic cleft


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Related to synaptic cleft: postsynaptic membrane

synaptic cleft

n.
The space between the cell membrane of an axon terminal and that of a neighboring cell with which it forms a synapse, across which a nerve impulse is transmitted. Also called synaptic gap.
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14) Thus, the concentrations of 5-HT and norepinephrine increase in the synaptic cleft.
sup][20] (2) Neonatal propofol exposure might increase GABAergic synaptic cleft distance.
fade] caused by cisatracurium seems to exhibit an amount of adenosine in the synaptic cleft which might be lower than that extant during 100% Fade, as at 50 Hz there is a higher activation of presynaptic [M.
Subsequently, neurotransmitter is released into the synaptic cleft and diffuses to the postsynaptic membrane to activate neurotransmitter receptors.
1) GLUTAMATE RELEASE AT SYNAPSE UP TO NO DIFFUSION: When an excitatory impulse, anterograde neurotransmission (ANT), spreads over the presynaptic terminal, the membrane depolarization causes glutamate release to synaptic cleft.
When an action potential travels along a nerve and arrives at the axon terminal, it triggers the secretion of a neurotransmitter that allows the passage of a signal from one neuron to its neighbour via the synaptic cleft.
This allows serotonin to accumulate in synaptic cleft and affects post-synaptic neuron.
Duloxetine and venlafaxine are serotonin-norepinephrine reuptake inhibitors (SNRIs), which can lead to increased concentration of both serotonin and norepinephrine in the synaptic cleft and potentiate their neuromodulatory effects.