Hence, the present study provides further evidence of a nongenomic membrane-related action of [T.sub.3] in the mature mammalian synaptosome
. Understanding of the mechanism of action of TH in adult mammalian brain has major implications in the higher mental functions and in the regulation of several neuropsychiatric disorders developed in thyroid dysfunctions in adult humans.
Differential effect of anionic and cationic drugs on the synaptosome
associated acetylcholinesterase activity of dog brain.
Cloning of neuronal mtDNA variants in cultured cells by synaptosome
fusion with mtDNA-less cells.
The resulting compound, called a synaptosome
, was then exposed to serotonin and other brain chemicals.
Comparative studies in synaptosome
formation: the preparation of synaptosomes
from the head ganglion of the squid, Loligo pealii.
It is in high concentration in the electric organ of the electric eel, Eletrophorus Electricus, an adaptation of a synaptosome
that depends on acetyl choline as the neurotransmitter.
These studies showed the neuroprotective effect of a potent inhibitor of free radical and lipid peroxidation in synaptosome
, antioxidant, against oxidative stress in both cell and animal model.
To detect Pin1 proteins in detergent-resistant dendritic rafts and PSD, synaptosome
fractions were effectively isolated from the frontal cortical tissues of human AD and normal control brains, and the synaptic markers PSD95 and Shank3 were enriched up to 9 and 8 times in synaptosome
fractions, respectively (Figure 1(b)).
A portion of this progress is represented in this special issue and reveals the identification of a specific source of ROS in the synaptosome
and the contributory impact of thioredoxin-interacting protein (TXNIP) on inflammasome activation.
montagui (Richardson et al., 1995), and these might provide an opportunity to examine dynamic aspects of presynaptic channel activity directly in their normal environment, rather than in isolated synaptosome
preparations (Umbach et al., 1984; Edry-Schiller et al., 1991).
Reduced mitochondrial function was observed in in vivo synaptosome
preparations, and although striatal dopamine levels were not decreased, there was an increased dopamine turnover and decreased motor activity.
In addition, the effect to the synapse formation and function were evaluated by setting the numerous spinal densities on dendrite of brain cortex (number of spines per 10 micrometer of dendrites) and mitochondrial function (mitochondrial oxygen efficiency) of hippocampal synaptosomes
(isolated presynaptic terminal) as an index.