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An immunosuppressive drug produced by the actinomycete Streptomyces tsukubaensis, C44H69NO12, used in combination with corticosteroids to prevent rejection of organ transplants.

[t(sukubaensis), specific epithet (after Mount Tsukuba, Japan, near which the actinomycete was discovered) + (m)acrol(ide) im(m)u(no)s(uppressant).]


n tacrolimus m, tacrolimús m (INN)
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In March 2005, the FDA posted a Public Health Advisory and Alerts for Healthcare Professionals regarding the potential cancer risk from the use tacrolimus and pimecrolimus products when applied to the skin to treat atopic dermatitis.
1% tacrolimus ointment after their vulvar lichen planus had failed to respond to at least one prior form of therapy.
In 2002, Children's Health System participated in a multi-center trial of tacrolimus use in childhood nephrotic syndrome (Panzarino et al.
From our Phase 1a data, we were encouraged that LIM-0705 is effective in redistributing tacrolimus away from key organs that are vulnerable to toxicity," said Dr.
ENVARSUS XR was approved by the FDA on 10 July 2015 for the prophylaxis of organ rejection in kidney transplant patients converted from tacrolimus immediate-release formulations in combination with other immunosupressants.
1% tacrolimus ointment and group II with clobetasol ointment for a period of six months.
6% for the immediate-release tacrolimus capsules treatment group, demonstrating Envarsus XR as non-inferior to immediate-release tacrolimus capsules.
Methods: To determine the role of CYP3A4 and CYP3A5 on tacrolimus metabolism, rats were divided into five groups as: group 1 (control group, tacrolimus only 1 mg/kg i.
In most reports, tacrolimus hepatotoxicity has been characterized by elevated levels of hepatocellular enzymes, either alone or with minimal cholestasis and hyperbilirubinemia.
A recent report by Zarrinpar and colleagues (1) used a "parabolic personalized dosing" (PPD) platform to manage dosing changes of tacrolimus in liver transplant patients.