tacrolimus


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ta·cro·li·mus

 (tə-krō′lə-məs)
n.
An immunosuppressive drug produced by the actinomycete Streptomyces tsukubaensis, C44H69NO12, used in combination with corticosteroids to prevent rejection of organ transplants.

[t(sukubaensis), specific epithet (after Mount Tsukuba, Japan, near which the actinomycete was discovered) + (m)acrol(ide) im(m)u(no)s(uppressant).]
Translations

tacrolimus

n tacrolimus m, tacrolimús m (INN)
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References in periodicals archive ?
XR (tacrolimus extended-release tablets) for the prophylaxis of rejection in kidney transplant patients who require or desire conversion from immediate release tacrolimus products to once-daily Envarsus[sup.
Tacrolimus acts like cyclosporine and its systemic use is mainly for the prevention of allograft rejection and the treatment of immune disease.
At the same time, because the trough level of tacrolimus was 2.
A previous clinical trial by other investigators showed that twice-weekly maintenance therapy with topical tacrolimus kept adult atopic dermatitis in remission for extended periods and reduced the incidence of eczema exacerbations (Allergy 2008;63:742-50).
Envarsus XR is an extended release formulation of tacrolimus being designed for once-daily dosing, flatter pharmacokinetics and greater bioavailability compared to twice-daily Prograf.
For tacrolimus the cross-reactivity of the metabolites in most current immunoassays is still substantial (up to 60%), which can cause an unpredictable overestimation of the true drug concentrations (8, 9).
Tacrolimus is an immune suppressant widely used in organ transplantation.
Certican with reduced exposure tacrolimus provided comparable efficacy with superior renal function maintained from month one to 24 versus control arm.
Table 1 compares the characteristics of patients transplanted for HCV treated with tacrolimus vs.
1% tacrolimus ointment after their vulvar lichen planus had failed to respond to at least one prior form of therapy.