The LNP is designed to deliver its non-integrating DNA payload to solid tumors, while an engineered promoter drives expression of a potent, inducible death protein only in the target cell
Currently available electroporation equipment is tailored to fit different types of applications depending on the researcher's target cell
or tissue types.
It will use a novel and replication deficient lentiviral vector in an inhaled formulation to selectively introduce a CFTR gene into the relevant target cell
. It is also planning to assess Oxford BioMedica's transgene repression in vector production system and develop stable producer cell lines for large scale production of the lentiviral vector.
These microbubbles bear antibodies on their surface, enabling them to bind specifically to a single desired target cell
Stability of the Recombinant Effector and Target Cell
In the current study, researchers report on a new class of drug-like molecules that exploit our increasingly nuanced understanding of another facet of apoptosis regulation to specifically target cell
death in cancer cells--work which has the potential to further expand our armamentarium of drugs to fight neoplastic disease."
Killers perform their functions either from a distance or when in contact with the target cell
. The cytotoxic effect of killers is realized in the target cell
plasma membrane by special proteins--perforins, granzymes, etc., which lead to the formation in this organoid of perforations (pores).
MPs alter target cell
function, for example, MPs isolated from diabetic patients have pro-thrombotic effects on target cells
"We know that enveloped viruses must fuse their membrane with the target cell
membrane in order to initiate infection, and blocking this step can prevent or treat infection, as has been clinically validated for HIV virus."
Nevertheless, it has been shown that CB-derived NK and lymphokine-activated killer cells are able to lyse non-cultured fresh leukemia blasts, readily respond to IL-2 and IL-12, and mediate relatively high levels of apoptosis-mediated cytotoxicity against target cell
lines (18), (19).
* Different hormones can exert the same or different actions on the same target cell
Different cell volume with high target cell
population between liver disease and homogygous hemoglobin E.