Moving forward, the scientists will seek to determine whether olfactory receptors are preferentially located on a specific taste cell
type, for example, sweet- or salt-detecting cells.
This supports the possibility that a single taste cell
may contain both taste and olfactory receptors.
By identifying novel genes and molecular pathways involved in shaping a taste cell
's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine-tune a person's taste perception to encourage healthier eating.
Shigemura et al., "Leptin suppresses mouse taste cell
responses to sweet compounds," Diabetes, vol.
Some studies indicate (a) that all bitter taste stimuli should generate indiscriminable afferent signals because each bitter-sensitive taste cell
expresses multiple classes of T2R (Chandrashekar et al., 2000); and (b) that animals cannot discriminate between isoaversive concentrations of different bitter taste stimuli (Aspen et al., 1999; Spector and Kopka, 2002).
The University of California, San Diego in collaboration with researchers at the Howard Hughes Medical Institute, National Institute of Dental and Craniofacial Research (NIDCR), and the National Institutes of Health (NIH) have isolated taste-receptor genes in order to provide the foundation for constructing methods of stimulating, or blocking, taste cell
The CALHM1 deficiency affects taste perception without interfering with taste cell
development or overall function.
All three taste cell
types undergo frequent turnover, with an average lifespan of 10-16 days.
Part 1 carries the title Biochemical events in taste reception and transduction; Part 2 is Ionic mechanisms of taste cell
activation; Part 3 Biochemical events in olfactory reception and transduction; Part 4a Ionic mechanisms of olfactory transduction; Part 4b Ionic mechanisms of olfactory transduction.
Additional studies revealed that the Lgr5-expressing cells were capable of becoming any one of the three major taste cell
Though scientists don't fully understand what follows, studies hint at a tantalizing, if convoluted, connection between gut taste cell
activity and metabolism.
"Detecting the sweetness of nutritive sugars is one of the most important tasks of our taste cells
. Many of us eat too much sugar and to help limit overconsumption, we need to better understand how a sweet taste cell
'knows' something is sweet," said Robert F.